Cartilage oligomeric matrix protein-deficient mice have normal skeletal development.
| العنوان: | Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. |
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| المؤلفون: | Svensson, Liz, Aszodi, Attila, Heinegård, Dick, Hunziker, Ernst B, Reinholt, Finn P, Fässler, Reinhard, Oldberg, Åke |
| المصدر: | Molecular and Cellular Biology. 22(12):4366-4371 |
| مصطلحات موضوعية: | Extracellular Matrix Proteins : metabolism, Glycoproteins : deficiency, Female, Glycoproteins : genetics, Glycoproteins : metabolism, Male, Mice, Inbred Strains, Mutant Strains, Reference Values, Skeleton, Reverse Transcriptase Polymerase Chain Reaction, Support, Non-U.S. Gov't, Tibia : growth & development, Tibia : anatomy & histology, Extracellular Matrix Proteins : genetics, Extracellular Matrix Proteins : deficiency, Cartilage : ultrastructure, Cartilage : growth & development, Cartilage : anatomy & histology, Animal, Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Cell- och molekylärbiologi, Medical and Health Sciences, Basic Medicine, Cell and Molecular Biology |
| الوصف: | Cartilage oligomeric matrix protein (COMP) belongs to the thrombospondin family and is a homopentamer primarily expressed in cartilage. Mutations in the COMP gene result in the autosomal dominant chondrodysplasias pseudoachondroplasia (PSACH) and some types of multiple epiphyseal dysplasia (MED), which are characterized by mild to severe short-limb dwarfism and early-onset osteoarthritis. We have generated COMP-null mice to study the role of COMP in vivo. These mice show no anatomical, histological, or ultrastructural abnormalities and show none of the clinical signs of PSACH or MED. Northern blot analysis and immunohistochemical analysis of cartilage indicate that the lack of COMP is not compensated for by any other member of the thrombospondin family. The results also show that the phenotype in PSACH/MED cartilage disorders is not caused by the reduced amount of COMP. |
| وصف الملف: | electronic |
| الوصول الحر: | https://lup.lub.lu.se/record/108431Test https://portal.research.lu.se/files/2678013/623613.pdfTest http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12024046&dopt=AbstractTest http://mcb.asm.org/cgi/content/full/22/12/4366?view=full&pmid=12024046Test http://dx.doi.org/10.1128/MCB.22.12.4366-4371.2002Test |
| قاعدة البيانات: | SwePub |
| تدمد: | 02707306 |
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| DOI: | 10.1128/MCB.22.12.4366-4371.2002 |