The differential-algebraic Windkessel model with power as input
| العنوان: | The differential-algebraic Windkessel model with power as input |
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| المؤلفون: | Pigot, Harry, Soltesz, Kristian |
| المصدر: | American Control Conference, 2022,GA, United States,-- 2022 American Control Conference (ACC) ELLIIT: the Linköping-Lund initiative on IT and mobile communication. :3006-3011 |
| مصطلحات موضوعية: | Modelling and simulation, cardiac afterload, heart evaluation, differential-algebraic equation, Teknik, Medicinteknik, Annan medicinteknik, Engineering and Technology, Medical Engineering, Other Medical Engineering, Elektroteknik och elektronik, Reglerteknik, Electrical Engineering, Electronic Engineering, Information Engineering, Control Engineering |
| الوصف: | The lack of methods to evaluate mechanical function of donated hearts in the context of transplantation imposes large precautionary margins, translating into a low utilization rate of donor organs. This has spawned research into cyber-physical models constituting artificial afterloads (arterial trees), that can serve to evaluate the contractile capacity of the donor heart.The Windkessel model is an established linear time-invariant afterload model, that researchers committed to creating a cyber-physical afterload have used as a template. With aortic volumetric flow as input and aortic pressure as output, it is not directly obvious how a Windkessel model will respond to changes in heart contractility.We transform the classic Windkessel model to relate power, rather than flow, to pressure. This alters the model into a differential-algebraic equation, albeit one that is straightforward to simulate. We then propose a power signal model, that is based on pressure and flow measurements and optimal in a Bayesian sense within the class of C2 signals. Finally, we show how the proposed signal model can be used to create relevant simulation scenarios, and use this to illustrate why it is problematic to use the Windkessel model as a basis for designing a clinically relevant artificial afterload. |
| وصف الملف: | electronic |
| الوصول الحر: | https://lup.lub.lu.se/record/1f769e42-89b0-435e-9edf-4366b90977faTest https://portal.research.lu.se/files/115310976/pigot2022differential.pdfTest http://dx.doi.org/10.23919/ACC53348.2022.9867889Test |
| قاعدة البيانات: | SwePub |
| DOI: | 10.23919/ACC53348.2022.9867889 |
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