Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes
| العنوان: | Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes |
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| المؤلفون: | Schölin, Anna, Törn, C, Nyström, L, Berne, Christian, Arnqvist, H, Blohme, G, Bolinder, J, Eriksson, Jan W, Kockum, I, Landin-Olsson, M, Östman, J, Karlsson, F Anders, Sundkvist, G, Björk, Elisabeth |
| المصدر: | Diabetic Medicine. 21(5):447-455 |
| مصطلحات موضوعية: | Adolescent, Adult, Autoantibodies/*blood, Body Mass Index, Body Weight, Diabetes Mellitus, Type 1/drug therapy/*immunology/pathology, Drug Administration Schedule, Female, Humans, Hypoglycemic Agents/administration & dosage, Insulin/administration & dosage, Islets of Langerhans/*immunology, Logistic Models, Male, Prospective Studies, Remission Induction, Research Support, Non-U.S. Gov't, Survival Analysis, Time Factors |
| الوصف: | Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM).Methods In Sweden, 362 patients (15–34 years), classified as Type 1 DM were included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA1c and insulin dosage over a median period after diagnosis of 5 years. Duration of remission, defined as an insulin maintenance dose ≤ 0.3 U/kg/24 h and HbA1c within the normal range, was analysed in relation to characteristics at diagnosis.Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1–73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab+), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20–24.9 kg/m2) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab+ remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions.Conclusion In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration. |
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| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-70080Test http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15089789&dopt=CitationTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 07423071 14645491 |
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| DOI: | 10.1111/j.1464-5491.2004.01175.x |