التفاصيل البيبلوغرافية
العنوان:
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
المؤلفون:
Wang, Anqi , Shen, Jiayi , Rodriguez, Alex A. , Saunders, Edward J. , Chen, Fei , Janivara, Rohini , Darst, Burcu F. , Sheng, Xin , Xu, Yili , Chou, Alisha J. , Benlloch, Sara , Dadaev, Tokhir , Brook, Mark N. , Plym, Anna , Sahimi, Ali , Hoffman, Thomas J. , Takahashi, Atushi , Matsuda, Koichi , Momozawa, Yukihide , Fujita, Masashi , Laisk, Triin , Figueredo, Jessica , Muir, Kenneth , Ito, Shuji , Liu, Xiaoxi , Uchio, Yuji , Kubo, Michiaki , Kamatani, Yoichiro , Lophatananon, Artitaya , Wan, Peggy , Andrews, Caroline , Lori, Adriana , Choudhury, Parichoy P. , Schleutker, Johanna , Tammela, Teuvo L. J. , Sipeky, Csilla , Auvinen, Anssi , Giles, Graham G. , Southey, Melissa C. , MacInnis, Robert J. , Cybulski, Cezary , Wokolorczyk, Dominika , Lubinski, Jan , Rentsch, Christopher T. , Cho, Kelly , Mcmahon, Benjamin H. , Neal, David E. , Donovan, Jenny L. , Hamdy, Freddie C. , Martin, Richard M. , Nordestgaard, Borge G. , Nielsen, Sune F. , Weischer, Maren , Bojesen, Stig E. , Roder, Andreas , Stroomberg, Hein V. , Batra, Jyotsna , Chambers, Suzanne , Horvath, Lisa , Clements, Judith A. , Tilly, Wayne , Risbridger, Gail P. , Gronberg, Henrik , Aly, Markus , Szulkin, Robert , Eklund, Martin , Nordstrom, Tobias , Pashayan, Nora , Dunning, Alison M. , Ghoussaini, Maya , Travis, Ruth C. , Key, Tim J. , Riboli, Elio , Park, Jong Y. , Sellers, Thomas A. , Lin, Hui-Yi , Albanes, Demetrius , Weinstein, Stephanie , Cook, Michael B. , Mucci, Lorelei A. , Giovannucci, Edward , Lindstrom, Sara , Kraft, Peter , Hunter, David J. , Penney, Kathryn L. , Turman, Constance , Tangen, Catherine M. , Goodman, Phyllis J. , Thompson, Ian M., Jr. , Hamilton, Robert J. , Fleshner, Neil E. , Finelli, Antonio , Parent, Marie-Elise , Stanford, Janet L. , Ostrander, Elaine A. , Koutros, Stella , Freeman, Laura E. Beane , Stampfer, Meir , Wolk, Alicja , Hakansson, Niclas , Andriole, Gerald L. , Hoover, Robert N. , Machiela, Mitchell J. , Sorensen, Karina Dalsgaard , Borre, Michael , Blot, William J. , Zheng, Wei , Yeboah, Edward D. , Mensah, James E. , Lu, Yong-Jie , Zhang, Hong-Wei , Feng, Ninghan , Mao, Xueying , Wu, Yudong , Zhao, Shan-Chao , Sun, Zan , Thibodeau, Stephen N. , McDonnell, Shannon K. , Schaid, Daniel J. , West, Catharine M. L. , Barnett, Gill , Maier, Christiane , Schnoeller, Thomas , Luedeke, Manuel , Kibel, Adam S. , Drake, Bettina F. , Cussenot, Olivier , Cancel-Tassin, Geraldine , Menegaux, Florence , Truong, Therese , Koudou, Yves Akoli , John, Esther M. , Grindedal, Eli Marie , Maehle, Lovise , Khaw, Kay-Tee , Ingles, Sue A. , Stern, Mariana C. , Vega, Ana , Gomez-Caamano, Antonio , Fachal, Laura , Rosenstein, Barry S. , Kerns, Sarah L. , Ostrer, Harry , Teixeira, Manuel R. , Paulo, Paula , Brandao, Andreia , Watya, Stephen , Lubwama, Alexander , Bensen, Jeannette T. , Butler, Ebonee N. , Mohler, James L. , Taylor, Jack A. , Kogevinas, Manolis , Dierssen-Sotos, Trinidad , Castano-Vinyals, Gemma , Cannon-Albright, Lisa , Teerlink, Craig C. , Huff, Chad D. , Pilie, Patrick , Yu, Yao , Bohlender, Ryan J. , Gu, Jian , Strom, Sara S. , Multigner, Luc , Blanchet, Pascal , Brureau, Laurent , Kaneva, Radka , Slavov, Chavdar , Mitev, Vanio , Leach, Robin J. , Brenner, Hermann , Chen, Xuechen , Holleczek, Bernd , Schoettker, Ben , Klein, Eric A. , Hsing, Ann W. , Kittles, Rick A. , Murphy, Adam B. , Logothetis, Christopher J. , Kim, Jeri , Neuhausen, Susan L. , Steele, Linda , Ding, Yuan Chun , Isaacs, William B. , Nemesure, Barbara , Hennis, Anselm J. M. , Carpten, John , Pandha, Hardev , Michael, Agnieszka , De Ruyck, Kim , De Meerleer, Gert , Ost, Piet , Xu, Jianfeng , Razack, Azad , Lim, Jasmine , Teo, Soo-Hwang , Newcomb, Lisa F. , Lin, Daniel W. , Fowke, Jay H. , Neslund-Dudas, Christine M. , Rybicki, Benjamin A. , Gamulin, Marija , Lessel, Davor , Kulis, Tomislav , Usmani, Nawaid , Abraham, Aswin , Singhal, Sandeep , Parliament, Matthew , Claessens, Frank , Joniau, Steven , Van den Broeck, Thomas , Gago-Dominguez, Manuela , Castelao, Jose Esteban , Martinez, Maria Elena , Larkin, Samantha , Townsend, Paul A. , Aukim-Hastie, Claire , Bush, William S. , Aldrich, Melinda C. , Crawford, Dana C. , Srivastava, Shiv , Cullen, Jennifer , Petrovics, Gyorgy , Casey, Graham , Wang, Ying , Tettey, Yao , Lachance, Joseph , Tang, Wei , Biritwum, Richard B. , Adjei, Andrew A. , Tay, Evelyn , Truelove, Ann , Niwa, Shelley , Yamoah, Kosj , Govindasami, Koveela , Chokkalingam, Anand P. , Keaton, Jacob M. , Hellwege, Jacklyn N. , Clark, Peter E. , Jalloh, Mohamed , Gueye, Serigne M. , Niang, Lamine , Ogunbiyi, Olufemi , Shittu, Olayiwola , Amodu, Olukemi , Adebiyi, Akindele O. , Aisuodionoe-Shadrach, Oseremen I. , Ajibola, Hafees O. , Jamda, Mustapha A. , Oluwole, Olabode P. , Nwegbu, Maxwell , Adusei, Ben , Mante, Sunny , Darkwa-Abrahams, Afua , Diop, Halimatou , Gundell, Susan M. , Roobol, Monique J. , Jenster, Guido , van Schaik, Ron H. N. , Hu, Jennifer J. , Sanderson, Maureen , Kachuri, Linda , Varma, Rohit , McKean-Cowdin, Roberta , Torres, Mina , Preuss, Michael H. , Loos, Ruth J. F. , Zawistowski, Matthew , Zollner, Sebastian , Lu, Zeyun , Van Den Eeden, Stephen K. , Easton, Douglas F. , Ambs, Stefan , Edwards, Todd L. , Magi, Reedik , Rebbeck, Timothy R. , Fritsche, Lars , Chanock, Stephen J. , Berndt, Sonja I. , Wiklund, Fredrik , Nakagawa, Hidewaki , Witte, John S. , Gaziano, J. Michael , Justice, Amy C. , Mancuso, Nick , Terao, Chikashi , Eeles, Rosalind A. , Kote-Jarai, Zsofia , Madduri, Ravi K. , Conti, David V. , Haiman, Christopher A.
المصدر:
Nature Genetics . 55(12):2065-2074
الوصف:
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
وصف الملف:
print
الوصول الحر:
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524994Test
قاعدة البيانات:
SwePub
