Plasma circulating cell-free mitochondrial DNA in social anxiety disorder
| العنوان: | Plasma circulating cell-free mitochondrial DNA in social anxiety disorder |
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| المؤلفون: | Lindqvist, Daniel, Furmark, Tomas, Lavebratt, Catharina, Ohlsson, Lars, Månsson, Kristoffer N T |
| المصدر: | Psychoneuroendocrinology. 148 |
| مصطلحات موضوعية: | circulating cell-free mitochondrial DNA, social anxiety disorder, cognitive behavioural therapy |
| الوصف: | Objective To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC). Methods In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual (9 to 11 weeks apart). SAD patients also received cognitive behavioral therapy (CBT) between the second and third time-point. Results SAD patients had significantly lower ccf-mtDNA compared to HCs at all time points, but ccf-mtDNA did not change significantly after CBT, and was not associated with severity of anxiety symptoms. PBMC mtDNA-cn did not significantly correlate with plasma ccf-mtDNA in patients. Conclusion This is the first report of lower ccf-mtDNA in patients with an anxiety disorder. Our findings could reflect a more chronic illness course in SAD patients with prolonged periods of psychological stress leading to decreased levels of ccf-mtDNA, but future longitudinal studies are needed to confirm or refute this hypothesis. |
| وصف الملف: | electronic |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-490367Test https://doi.org/10.1016/j.psyneuen.2022.106001Test https://uu.diva-portal.org/smash/get/diva2:1717691/FULLTEXT01.pdfTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 03064530 18733360 |
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| DOI: | 10.1016/j.psyneuen.2022.106001 |