Vecntricular volume in relation to lumbar CSF levels of amyloid-beta 1-42, tau and phosphorylated tau in iNPH, is there a dilution effect?
| العنوان: | Vecntricular volume in relation to lumbar CSF levels of amyloid-beta 1-42, tau and phosphorylated tau in iNPH, is there a dilution effect? |
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| المؤلفون: | Liden, Simon, Farahmand, Dan, Laurell, Katarina, 1967 |
| المصدر: | Fluids and Barriers of the CNS. 19(1) |
| مصطلحات موضوعية: | Normal Pressure Hydrocephalus, Ventricular volume, Amyloid-beta, Tau, Cerebrospinal fluid |
| الوصف: | Background: Levels of the biomarkers amyloid-beta 1-42 (A beta 42), tau and phosphorylated tau (p-tau) are decreased in the cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH). The mechanism behind this is unknown, but one potential explanation is dilution by excessive CSF volumes. The aim of this study was to investigate the presence of a dilution effect, by studying the relationship between ventricular volume (VV) and the levels of the CSF biomarkers. Methods: In this cross-sectional observational study, preoperative magnetic resonance imaging (MRI) and lumbar CSF was acquired from 136 patients with a median age of 76 years, 89 men and 47 females, selected for surgical treat-ment for iNPH. The CSF volume of the lateral and third ventricles was segmented on MRI and related to preoperative concentrations of A beta 42, tau and p-tau. Results: In the total sample W (Median 140.7 mL) correlated weakly (r(s) = - 0.17) with A beta 42 (Median 534 pg/mL), but not with tau (Median 216 pg/mL) nor p-tau (Median 31 pg/mL). In a subgroup analysis, the correlation between W and A beta 42 was only present in the male group (r(s) = - 0.22, p= 0.038). Further, A beta 42 correlated positively with tau (r(s) =0.30, p= 0.004) and p-tau (r(s) = 0.26, p = 0.012) in males but not in females. Conclusions: The findings did not support a major dilution effect in iNPH, at least not in females. The only result in favor for dilution was a weak negative correlation between VV and A beta 42 but not with the other lumbar CSF biomarkers. The different results between males and females suggest that future investigations of the CSF pattern in iNPH would gain from sex-based subgroup analysis. |
| وصف الملف: | electronic |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-481693Test https://doi.org/10.1186/s12987-022-00353-9Test https://uu.diva-portal.org/smash/get/diva2:1687762/FULLTEXT01.pdfTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 20458118 |
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| DOI: | 10.1186/s12987-022-00353-9 |