Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue
| العنوان: | Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue |
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| المؤلفون: | Niessl, Julia, Sekine, Takuya, Lange, Joshua, Konya, Viktoria, Forkel, Marianne, Maric, Jovana, Rao, Anna, Mazzurana, Luca, Kokkinou, Efthymia, Weigel, Whitney, Llewellyn-Lacey, Sian, Hodcroft, Emma B., Karlsson, Annika C., Fehrm, Johan, Sundman, Joar, Price, David A., Mjösberg, Jenny, Friberg, Danielle, Buggert, Marcus |
| المصدر: | Science immunology. 6(64) |
| الوصف: | Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed individuals compared with SARS-CoV-2–reactive CD8+ T cells. However, large numbers of memory CD8+ T cells reside in tissues, feasibly harboring localized SARS-CoV-2–specific immune responses. To test this idea, we performed a comprehensive functional and phenotypic analysis of virus-specific T cells in tonsils, a major lymphoid tissue site in the upper respiratory tract, and matched peripheral blood samples obtained from children and adults before the emergence of COVID-19 (coronavirus disease 2019). We found that SARS-CoV-2–specific memory CD4+ T cells could be found at similar frequencies in the tonsils and peripheral blood in unexposed individuals, whereas functional SARS-CoV-2–specific memory CD8+ T cells were almost only detectable in the tonsils. Tonsillar SARS-CoV-2–specific memory CD8+ T cells displayed a follicular homing and tissue-resident memory phenotype, similar to tonsillar Epstein-Barr virus–specific memory CD8+ T cells, but were functionally less potent than other virus-specific memory CD8+ T cell responses. The presence of preexisting tissue-resident memory CD8+ T cells in unexposed individuals could potentially enable rapid sentinel immune responses against SARS-CoV-2. |
| وصف الملف: | electronic |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-460082Test https://doi.org/10.1126/sciimmunol.abk0894Test https://uu.diva-portal.org/smash/get/diva2:1620061/FULLTEXT01.pdfTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 24709468 |
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| DOI: | 10.1126/sciimmunol.abk0894 |