IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5
| العنوان: | IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5 |
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| المؤلفون: | Shin, J-H, Janer, M, McNeney, B, Blay, S, Deutsch, K, Sanjeevi, C B, Kockum, I, Lernmark, A, Graham, J, Arnqvist, Hans, Björck, Elizabeth, Eriksson, Jan, Nyström, Lennarth, Ohlson, Lars Olof, Scherstén, Bengt, Ostman, Jan, Aili, M, Bååth, L E, Carlsson, E, Edenwall, H, Forsander, G, Granström, B W, Gustavsson, I, Hanås, R, Hellenberg, L, Hellgren, H, Holmberg, E, Hörnell, H, Ivarsson, Sten-A, Johansson, C, Jonsell, G, Kockum, K, Lindblad, B, Lindh, A, Ludvigsson, J, Myrdal, U, Neiderud, J, Segnestam, K, Sjöblad, S, Skogsberg, L, Strömberg, L, Ståhle, U, Thalme, B, Tullus, K, Tuvemo, T, Wallensteen, M, Westphal, O, Aman, J |
| المصدر: | Genes and Immunity. 8(6):503-512 |
| مصطلحات موضوعية: | Adolescent, Adult, Autoantibodies/blood/*immunology, Case-Control Studies, Child, Preschool, Diabetes Mellitus, Type 1/*genetics/*immunology/metabolism, Female, GTP-Binding Proteins/*genetics/metabolism, Humans, Infant, Newborn, Male, Polymorphism, Single Nucleotide, Sweden, MEDICINE, MEDICIN |
| الوصف: | In a large case-control study of Swedish incident type I diabetes patients and controls, 0–34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 10-13) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 10-5) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease. |
| وصف الملف: | |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14463Test http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17641683&dopt=CitationTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 14664879 14765470 |
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| DOI: | 10.1038/sj.gene.6364413 |