Wide temporal horns are associated with cognitive dysfunction, as well as impaired gait and incontinence
| العنوان: | Wide temporal horns are associated with cognitive dysfunction, as well as impaired gait and incontinence |
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| المؤلفون: | Lilja-Lund, Otto, Kockum, Karin, Hellström, Per, Söderström, Lars, Nyberg, Lars, 1966, Laurell, Katarina |
| المصدر: | Scientific Reports. 10(1) |
| الوصف: | The association between morphology of the brain and symptoms of suspected idiopathic normal pressure hydrocephalus (iNPH) is largely unknown. We investigated how ventricular expansion (width of the temporal horns [TH], callosal angle [CA], and Evans' index [EI]) related to symptom severity in suspected iNPH. Participants (n=168; 74.9 years +/- SD 6.7; 55% females) from the general population underwent neurological examination, computed tomography, and neuropsychological testing. Multiple linear regression analysis revealed that wide TH was independently associated with all examined iNPH symptoms (p<0.01) except for fine-motor performance, whereas a narrow CA only was associated to specific motor and cognitive functions (p<0.05). TH and EI correlated significantly with incontinence (r(s) 0.17 and r(s) 0.16; p<0.05). In conclusion, wide TH was significantly associated with most iNPH-symptoms. This finding potentially reflects the complex nature of the hippocampus, however further studies are needed to demonstrate functional connectivity. |
| وصف الملف: | electronic |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177175Test https://doi.org/10.1038/s41598-020-75381-2Test https://umu.diva-portal.org/smash/get/diva2:1505619/FULLTEXT01.pdfTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-020-75381-2 |