Natural-Cause Mortality and Long-Term Exposure to Particle Components: An Analysis of 19 European Cohorts within the Multi-Center ESCAPE Project
| العنوان: | Natural-Cause Mortality and Long-Term Exposure to Particle Components: An Analysis of 19 European Cohorts within the Multi-Center ESCAPE Project |
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| المؤلفون: | Beelen, Rob, Hoek, Gerard, Raaschou-Nielsen, Ole, Stafoggia, Massimo, Andersen, Zorana Jovanovic, Weinmayr, Gudrun, Hoffmann, Barbara, Wolf, Kathrin, Samoli, Evangelia, Fischer, Paul H., Nieuwenhuijsen, Mark J., Xun, Wei W., Katsouyanni, Klea, Dimakopoulou, Konstantina, Marcon, Alessandro, Vartiainen, Erkki, Lanki, Timo, Yli-Tuomi, Tarja, Oftedal, Bente, Schwarze, Per E., Nafstad, Per, De Faire, Ulf, Pedersen, Nancy L., Otstenson, Claes-Goran, Fratiglioni, Laura, Penell, Johanna, Korek, Michal, Pershagen, Goran, Eriksen, Kirsten Thorup, Overvad, Kim, Sorensen, Mette, Eeftens, Marloes, Peeters, Petra H., Meliefste, Kees, Wang, Meng, Bueno-de-Mesquita, H. Bas, Sugiri, Dorothea, Kramer, Ursula, Heinrich, Joachim, de Hoogh, Kees, Key, Timothy, Peters, Annette, Hampel, Regina, Concin, Hans, Nagel, Gabriele, Jaensch, Andrea, Ineichen, Alex, Tsai, Ming-Yi, Schaffner, Emmanuel, Probst-Hensch, Nicole M., Schindler, Christian, Ragettli, Martina S., Vilier, Alice, Clavel-Chapelon, Francoise, Declercq, Christophe, Ricceri, Fulvio, Sacerdote, Carlotta, Galassi, Claudia, Migliore, Enrica, Ranzi, Andrea, Cesaroni, Giulia, Badaloni, Chiara, Forastiere, Francesco, Katsoulis, Michail, Trichopoulou, Antonia, Keuken, Menno, Jedynska, Aleksandra, Kooter, Ingeborg M., Kukkonen, Jaakko, Sokhi, Ranjeet S., Vineis, Paolo, Brunekreef, Bert |
| المصدر: | Journal of Environmental Health Perspectives. 123(6):525-533 |
| الوصف: | Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. Objectives: Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Methods: Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori-selected components of particulate matter ( PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions <= 2.5 mu m (PM2.5) and <= 10 mu m (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. Results: The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200ng/m(3)). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced. Conclusions: Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5. |
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| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-119246Test https://doi.org/10.1289/ehp.1408095Test |
| قاعدة البيانات: | SwePub |
| تدمد: | 00916765 15529924 |
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| DOI: | 10.1289/ehp.1408095 |