Personalized treatment of hepatitis C genotype 1a in Norway and Sweden 2014-2016: a study of treatment outcome in patients with or without resistance-based DAA-therapy
| العنوان: | Personalized treatment of hepatitis C genotype 1a in Norway and Sweden 2014-2016: a study of treatment outcome in patients with or without resistance-based DAA-therapy |
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| المؤلفون: | Kileng, Hege, Kjellin, Midori, Akaberi, Dario, Bergfors, Assar, Duberg, Ann-Sofi, Docent, 1957, Wesslén, Lars, Danielsson, Astrid, Gangsøy Kristiansen, Magnhild, Gutteberg, Tore, Goll, Rasmus, Lannergård, Anders, Lennerstrand, Johan |
| المصدر: | Scandinavian Journal of Gastroenterology. 53(10-11):1347-1353 |
| مصطلحات موضوعية: | Baseline resistance, NS5A, Q80K, hepatitis C virus, resistance-associated substitution, sustained virologic response |
| الوصف: | OBJECTIVES: Resistance-associated substitutions (RASs) may impair treatment response to direct-acting antivirals (DAA) in hepatitis C virus (HCV) treatment. We investigated the effects of baseline NS3-RASs (Q80K and R155K) and clinically relevant NS5A-RASs in patients with HCV genotype (GT) 1a infection on treatment outcome, with or without resistance-based DAA-treatment. This multi-center study was carried out between 2014 and 2016.PATIENTS/METHODS: Treatment in the intervention group (n = 92) was tailored to baseline resistance. Detection of NS3-RAS led to an NS5A-inhibitor-based regimen and detection of NS5A-RAS to a protease-inhibitor regimen. Patients without baseline RAS in the intervention group and all patients in the control group (n = 101) received recommended standard DAA-treatment.RESULTS: The sustained virologic response rates (SVR) in the intervention and control groups were 97.8% (90/92) and 93.1% (94/101), respectively (p = .174). A trend toward higher SVR-rate in cirrhotic patients (p = .058) was noticed in the intervention group compared to the control group with SVR-rates 97.5% (39/40) and 83.3% (35/42), respectively. All patients with baseline NS3 (Q80K/R155K) or NS5A-RASs in the intervention group achieved SVR with personalized resistance-based treatment. In the control group, five patients with Q80K or R155K at baseline were treated with simeprevir + sofosbuvir and treatment failed in two of them. Furthermore, one of three patients who failed ledipasvir + sofosbuvir treatment had NS5A-RASs at baseline.CONCLUSIONS: In line with the findings of the OPTIMIST-2 trial for Q80K and the EASL-guidelines 2016 for NS5A-RASs, baseline RASs appeared to have an impact on treatment outcome albeit a statistical significance was not observed in this low-prevalence population. |
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| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70125Test https://doi.org/10.1080/00365521.2018.1511824Test |
| قاعدة البيانات: | SwePub |
| تدمد: | 00365521 15027708 |
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| DOI: | 10.1080/00365521.2018.1511824 |