التفاصيل البيبلوغرافية
| العنوان: |
Pleuromutilin 2-[(diphenylmethyl)thio] acetic acid ester with anti-drug resistant bacteria activity and a method of preparing the same |
| Patent Number: |
11512,049 |
| تاريخ النشر: |
November 29, 2022 |
| Appl. No: |
17/239582 |
| Application Filed: |
April 24, 2021 |
| مستخلص: |
A compound with anti-drug resistant bacteria activity having the formula (I): [chemical expression included] (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed. |
| Inventors: |
Zhao, Qianqian (Xi'an, CN); Zhao, Yuqing (Xi'an, CN); Yang, Dan (Xi'an, CN); Li, Jingyi (Xi'an, CN); Xin, Liang (Xi'an, CN); Bian, Ruina (Xi'an, CN); Zhang, Jie (Xi'an, CN); Li, Han (Xi'an, CN); Tian, Bin (Xi'an, CN); Wang, Yongbo (Xi'an, CN); Liang, Chengyuan (Xi'an, CN); Qi, Liang (Xi'an, CN); Mao, Gennian (Xi'an, CN) |
| Assignees: |
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (Xi'an, CN) |
| Claim: |
1. A compound with anti-drug resistant bacteria activity having the following formula [chemical expression included] |
| Claim: |
2. A method of preparing the compound of formula (I) of claim 1 , comprising: reacting a compound of formula (II) with a compound of formula (III) to obtain the compound of formula (I), [chemical expression included] |
| Claim: |
3. The method of claim 2 , wherein the reaction of the compound of formula (II) with the compound of formula (III) comprises the following steps: placing the compound of formula (II) and the compound of formula (III), in a molar ratio of 1:1 to 1:1.3, in a reactor; adding an organic solvent and a catalytic amount of triethylamine under a nitrogen atmosphere to obtain a reaction mixture; heating the reaction mixture at 20-60° C. for 3-6 hours; extracting the reaction mixture with ethyl acetate to obtain a crude product; and purifying the crude product on a silica gel chromatography column with petroleum ether and ethyl acetate as an eluent to obtain the compound of formula (I). |
| Claim: |
4. The method of claim 3 , wherein the organic solvent is selected from the group consisting of toluene, dichloromethane and N,N-dimethylformamide. |
| Claim: |
5. The method of claim 4 , wherein the organic solvent is dichloromethane. |
| Claim: |
6. The method of claim 3 , wherein the molar ratio of the compound of formula (II) and the compound of formula (III) is 1:1.1. |
| Claim: |
7. The method of claim 3 , wherein the reaction mixture is heated at 25° C. |
| Claim: |
8. The method of claim 3 , wherein the reaction mixture is heated for 5 hours. |
| Claim: |
9. The method of claim 3 , wherein the eluent is petroleum ether:ethyl acetate=4:1. |
| Claim: |
10. A method of preparing the compound of formula (I) of claim 1 , comprising: reacting a compound of formula (II) with a compound of formula (IV) to obtain the compound of formula (I): [chemical expression included] |
| Claim: |
11. The method of claim 10 , wherein the reaction of the compound of formula (II) with the compound of formula (IV) comprises the following steps: placing the compound of formula (II), a catalyst, and an ionic liquid in a reactor under nitrogen atmosphere, the catalyst being 12-molybdosilicic acid hydrate of formula H 6 Mo 12 O 41 Si; adding the compound of formula (IV) to the reactor to form a reaction mixture; heating the reaction mixture at 20-50° C. for 4-8 hours; placing the reaction mixture in a separating funnel to separate a crude product; purifying the crude product by recrystallization in methanol to obtain the compound of formula (I); and recycling the ionic liquid. |
| Claim: |
12. The method of claim 11 , wherein the ionic liquid is selected from the group consisting of 1-octyl-3-methylimidazolium and hexafluorophosphate, 1-hexyl-3-methylimidazolium tetrafluoroborate and 1-butyl-3-methylimidazolium tetrafluoroborate of formula [BMIM][BF4]. |
| Claim: |
13. The method of claim 12 , wherein the ionic liquid is 1-butyl-3-methylimidazolium tetrafluoroborate. |
| Claim: |
14. The method of claim 11 , wherein the compound of formula (II) and the compound (IV) have a molar ratio of 1:1 to 1:1.3. |
| Claim: |
15. The method of claim 14 , wherein the molar ratio of the compound of formula (II) and the compound of formula (IV) is 1:1.1. |
| Claim: |
16. The method of claim 11 , wherein the reaction mixture is heated at 30° C. |
| Claim: |
17. The method of claim 11 , wherein the reaction mixture is heated for 6 hours. |
| Patent References Cited: |
7045524 May 2006 Dean |
| Primary Examiner: |
Muresan, Ana Z |
| رقم الانضمام: |
edspgr.11512049 |
| قاعدة البيانات: |
USPTO Patent Grants |
