Patent
Compositions and methods for the treatment of orthopedic disease or injury
| العنوان: | Compositions and methods for the treatment of orthopedic disease or injury |
|---|---|
| Patent Number: | 10130,687 |
| تاريخ النشر: | November 20, 2018 |
| Appl. No: | 13/976617 |
| Application Filed: | January 05, 2012 |
| مستخلص: | Methods for reducing the severity of an arthritic condition or repairing an osteochondral defect are carried out by administering to a subject compositions comprising a member of the matrilin family of proteins, e.g., a matrilin protein, fragment thereof, or nucleic acid encoding the protein or fragment. |
| Inventors: | Chen, Qian (Barrington, RI, US); Jayasuriya, Chathuraka T. (North Providence, RI, US) |
| Assignees: | Rhode Island Hospital (Providence, RI, US) |
| Claim: | 1. A method for promoting cartilage formation in a subject in need thereof, comprising administering to said subject a composition comprising a purified matrilin protein, thereby promoting cartilage formation in said subject, wherein said composition is administered directly into or onto the cartilage of an articulating joint or osteochondral tissue, and wherein said matrilin protein comprises the amino acid sequence of SEQ ID NO: 1, amino acids 29-440 of SEQ ID NO: 1, or SEQ ID NO: 4. |
| Claim: | 2. The method of claim 1 , wherein said composition further comprises a matrilin-1 protein. |
| Claim: | 3. The method of claim 1 , wherein said articulating joint comprises a knee, hip, elbow, or shoulder. |
| Claim: | 4. The method of claim 1 , wherein said osteochondral tissue comprises a vertebra. |
| Claim: | 5. The method of claim 1 , wherein said composition is administered by injection. |
| Claim: | 6. The method of claim 1 , wherein said composition is formulated as a biologic glue or cement. |
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| Primary Examiner: | Xie, Xiaozhen |
| Attorney, Agent or Firm: | Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. Beattie, Ingrid A. |
| رقم الانضمام: | edspgr.10130687 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |