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Compounds for the treatment of inflammatory disorders

التفاصيل البيبلوغرافية
العنوان: Compounds for the treatment of inflammatory disorders
Patent Number: 8,569,336
تاريخ النشر: October 29, 2013
Appl. No: 13/127953
Application Filed: November 09, 2009
مستخلص: This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. [chemical expression included]
Inventors: Tong, Ling (Warren, NJ, US); Lavey, Brian J. (New Providence, NJ, US); Shankar, Bandarpalle B. (Branchburg, NJ, US); Kim, Seong Heon (Livington, NJ, US); Yu, Wensheng (Edison, NJ, US); Kozlowski, Joseph A. (Princeton, NJ, US); Wong, Michael K. C. (Somerset, NJ, US); Chen, Lei (Roselle Park, NJ, US); Zhou, Guowei (Somerset, NJ, US); Rizvi, Razia K. (Bloomfield, NJ, US); Feltz, Robert (Washington, PA, US); Kosinski, Aneta Maria (South Amboy, NJ, US); Yang, De-Yi (Morris Plains, NJ, US); Dai, Chaoyang (Acton, MA, US); Fire, Luke (Cambridge, MA, US); Girijavallabhan, Vinay (Denville, NJ, US); Li, Dansu (Reading, MA, US); Popovici-Muller, Janeta (Waltham, MA, US); Richard, Judson E. (Kittery, ME, US); Rosner, Kristin E. (Watertown, MA, US); Siddiqui, M. Arshad (Newton, MA, US); Yang, Liping (Arlington, MA, US)
Claim: 1. A compound selected from the group consisting of: [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] or a pharmaceutically acceptable salt thereof.
Claim: 2. The compound of claim 1 , selected from the group consisting of: [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] or a pharmaceutically acceptable salt thereof.
Claim: 3. The compound of claim 2 , selected from the group consisting of: [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] or a pharmaceutically acceptable salt thereof.
Claim: 4. A pharmaceutical composition comprising at least one compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
Current U.S. Class: 514/302
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Other References: U.S. Appl. No. 13/120,728, commonly assigned. cited by examiner
U.S. Appl. No. 13/120,730, commonly assigned. cited by examiner
PCT International Search Report dated May 10, 2011 corresponding to PCT Application No. PCT/US2009/063669. cited by applicant
Knaggs, A., et al., “Biotransfonnation of Alosetron: Mechanism of Hydantoin Formation”, Tetrahedron Letters, vol. 36, No. 3, pp. 477-480 (1995). cited by applicant
Notice of Allowance mailed Jan. 3, 2013 from U.S. Appl. No. 13/120,730, which application published as US2011/0288077. cited by applicant
Assistant Examiner: Coppins, Janet L
Primary Examiner: Saeed, Kamal
Attorney, Agent or Firm: Meade, Eric A.
Camara, Valerie J.
رقم الانضمام: edspgr.08569336
قاعدة البيانات: USPTO Patent Grants
الوصف
الوصف غير متاح.