Patent
Treatment of attention-deficit/hyperactivity disorder
| العنوان: | Treatment of attention-deficit/hyperactivity disorder |
|---|---|
| Patent Number: | 8,222,278 |
| تاريخ النشر: | July 17, 2012 |
| Appl. No: | 12/475440 |
| Application Filed: | May 29, 2009 |
| مستخلص: | 3-(5,6-Dichloro-pyridin-3-yl)-1S,5S-3,6-diazabicyclo[3.2.0]heptane and salts thereof are effective nicotinic receptor agonist compounds that demonstrated pharmacological effect for symptoms associated with attention-deficit/hyperactivity disorder. |
| Inventors: | Bain, Earle E. (Libertyville, IL, US); Abi-Saab, Walid M. (Dornach, CH); Dutta, Sandeep (Gurnee, IL, US); Garimella, Tushar S. (Skokie, IL, US); Awni, Walid M. (Libertyville, IL, US); Saltarelli, Mario D. (Lake Bluff, IL, US) |
| Assignees: | Abbott Laboratories (Abbott Park, IL, US) |
| Claim: | 1. A method of treating attention-deficit/hyperactivity disorder in a subject in need thereof, comprising administering to a human patient in need of treatment for attention-deficit/hyperactivity disorder an amount of 3-(5,6-dichloro-pyridin-3-yl)-1S,5S-3,6-diazabicyclo[3.2.0]heptane or salt thereof that is 4 milligrams administered twice in a twenty-four hour period and the amount of 3-(5,6-dichloro-pyridin-3-yl)-1S,5S-3,6-diazabicyclo[3.2.0]heptane or salt thereof administered provides a plasma area under the curve (AUC) ratio that reduces symptom severity while minimizing adverse drug effect. |
| Claim: | 2. The method of claim 1 , wherein the administration of 3-(5,6-dichloro-pyridin-3-yl)-1S,5S-3,6-diazabicyclo[3.2.0]heptane or salt thereof provides a mean Cmax that is from about 5-15 ng/mL. |
| Claim: | 3. The method of claim 1 , wherein the administration of 3-(5,6-dichloro-pyridin-3-yl)-1S,5S-3,6-diazabicyclo[3.2.0]heptane or salt thereof provides an AUC 12 for 4 mg BID ranged that is from about 72-114 ng.hr/mL. |
| Current U.S. Class: | 514/338 |
| Patent References Cited: | 6809105 October 2004 Schrimpf et al. 7351833 April 2008 Wayne et al. 7354937 April 2008 Buckley et al. 7498444 March 2009 Wayne et al. 7538226 May 2009 Buckley et al. 2004/0242641 December 2004 Buckley et al. 2004/0242644 December 2004 Buckley et al. WO2004/106342 December 2004 |
| Other References: | International Search Report dated Sep. 24, 2009. cited by other |
| Primary Examiner: | Kim, Jennifer M |
| Attorney, Agent or Firm: | Mueller, Lisa V. Michael Best & Friedrich LLP |
| رقم الانضمام: | edspgr.08222278 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |