التفاصيل البيبلوغرافية
| العنوان: |
Stable liquid preparation of complex vitamin for internal use |
| Patent Number: |
5,578,600 |
| تاريخ النشر: |
November 26, 1996 |
| Appl. No: |
08/323,344 |
| Application Filed: |
October 14, 1994 |
| مستخلص: |
Described is a stable liquid preparation of complex vitamin for internal use. The preparation containing vitamin B.sub.1 and vitamin B.sub.12, and as a sweetening agent, a sugar alcohol. The pH of the preparation has been adjusted to 3.5 to 4.5. |
| Inventors: |
Murata, Yutaka (Inba-mura, JPX); Kikuchi, Yuko (Tokyo, JPX); Ohsugi, Tomohiko (Narita, JPX); Aoki, Noriko (Narita, JPX); Murata, Teiji (Shisui-machi, JPX); Kurazumi, Toshiaki (Narita, JPX); Iwasa, Akira (Yotsukaido, JPX) |
| Assignees: |
SS Pharmaceutical Co., Ltd. (Tokyo, JPX) |
| Claim: |
We claim |
| Claim: |
1. A stable liquid preparation of a complex vitamin for internal use, said liquid preparation having an adjusted pH of 3.5 to 4.5, consisting essentially of |
| Claim: |
a) a vitamin combination of at least vitamins B.sub.1 and B.sub.12 ; |
| Claim: |
b) a sugar alcohol as a sweetening agent; and |
| Claim: |
c) at least one other component selected from the group consisting of drug efficacy ingredients, crude drug ingredients, solubilizers, preservatives, coloring agents and perfumes. |
| Claim: |
2. The preparation according to claim 1, wherein vitamin B.sub.1 is thiamine or a derivative thereof or a salt of thiamine or the thiamine derivative; and vitamin B.sub.12 is cyanocobalamine. |
| Claim: |
3. The preparation according to claim 1 or 2, wherein said sugar alcohol is xylitol, maltitol or sorbitol. |
| Claim: |
4. The preparation according to claim 1, wherein citric, malic, tartaric or succinic acid or a salt thereof regulates the pH of the preparation to within the stated range in an amount not greater than 0.5 g per preparation. |
| Claim: |
5. The preparation according to claim 1, wherein the amount of said sugar alcohol in the preparation ranges from 0.5-20 g per 50 ml of liquid preparation. |
| Claim: |
6. The preparation according to claim 1, wherein said amount of sugar alcohol ranges from 1-15 g. |
| Claim: |
7. The preparation according to claim 1, wherein the amount of said vitamin B.sub.12 ranges from 1-5,000 .mu.g per 50 ml of liquid preparation. |
| Claim: |
8. The preparation according to claim 1, wherein the amount of said vitamin B.sub.1 ranges from 1-50 mg per 50 ml of liquid preparation. |
| Current U.S. Class: |
514/276; 514/394 |
| Current International Class: |
A61K 3151; A61K 31415 |
| Patent References Cited: |
4806354 February 1989 Green |
| Other References: |
Database WPI, Derwent Publications, AN-90-332333, JP-A-2 240 025, Sep. 25, 1990. |
| Primary Examiner: |
Dees, Jos e G. |
| Assistant Examiner: |
Cebulak, Mary C. |
| Attorney, Agent or Firm: |
Oblon, Spivak, McClelland, Maier & Neustadt, P.C. |
| رقم الانضمام: |
edspgr.05578600 |
| قاعدة البيانات: |
USPTO Patent Grants |
