التفاصيل البيبلوغرافية
| العنوان: |
Method, System and Computer Simulation Environment for Testing of Monitoring and Control Strategies in Diabetes |
| Document Number: |
20100179768 |
| تاريخ النشر: |
July 15, 2010 |
| Appl. No: |
12/664444 |
| Application Filed: |
June 20, 2008 |
| مستخلص: |
A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes. |
| Inventors: |
Kovatchev, Boris P. (Charlottesville, VA, US); Breton, Marc D. (Charlottesville, VA, US); Cobelli, Claudio (Padova, IT); Dalla Man, Chiara (Venice, IT) |
| Assignees: |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, VA, US) |
| Claim: |
1. A computer method for testing of monitoring and/or treatment strategies for diabetes using a computer simulation environment. |
| Claim: |
2. The method of claim 1, wherein said testing method comprises: representation of the human metabolic system, wherein said representation of the human metabolic system comprises: applying a mathematical model of the human metabolic system; and providing a plurality of instances of a simulated subject, creating a simulated population. |
| Claim: |
3. The method of claim 2, wherein said population is representative of the general diabetic population. |
| Claim: |
4. The method of claim 2, wherein said plurality of instances is about 300. |
| Claim: |
5. The method of claim 2, wherein said plurality of instances is about 200. |
| Claim: |
6. The method of claim 2, wherein said plurality of instances is about 100. |
| Claim: |
7. The method of claim 2, wherein said plurality of instances is less than about 100. |
| Claim: |
8. The method of claim 2, wherein said plurality of instances is greater than about 300. |
| Claim: |
9. The method of claim 1, wherein said testing method comprises a representation of the errors of continuous glucose monitoring sensor. |
| Claim: |
10. The method of claim 1, wherein said testing method comprises a representation of subcutaneous insulin delivery via insulin pump. |
| Claim: |
11. The method of claim 1, providing an interactive module for allowing a user or device to interact with said with said testing method to implement said testing method. |
| Claim: |
12. A computer simulation system environment for testing of monitoring and/or treatment strategies for diabetes. |
| Claim: |
13. The system of claim 12, wherein said computer simulation system environment comprises: a representation module of the human metabolic system, wherein said representation module comprises a processor configured to: apply a mathematical model means of the human metabolic system, and provide a plurality of instances of simulated subjects comprising a simulated population. |
| Claim: |
14. The system of claim 13, wherein said population is representative of the general diabetic population. |
| Claim: |
15. The system of claim 13, wherein said plurality of instances is about 300. |
| Claim: |
16. The system of claim 13, wherein said plurality of instances is about 200. |
| Claim: |
17. The system of claim 13, wherein said plurality of instances is about 100. |
| Claim: |
18. The system of claim 13, wherein said plurality of instances is less than about 100. |
| Claim: |
19. The system of claim 13, wherein said plurality of instances is greater than about 300. |
| Claim: |
20. The system of claim 12, wherein said computer simulation system environment for testing comprises: a simulated monitoring sensor, said simulated monitoring sensor comprises a representation of the errors of continuous glucose monitoring sensor. |
| Claim: |
21. The system of claim 12, wherein said computer simulation system environment for testing comprises: a simulated insulin pump, said simulated insulin pump comprises a representation of subcutaneous insulin delivery via insulin pump. |
| Claim: |
22. The system of claim 12, further comprises: an interactive module, said interactive module for allowing a user or device to interact with said with said computer simulation system environment for testing for implementing said testing. |
| Claim: |
23. A computer program product comprising a computer useable medium having computer program logic for enabling at least one processor in a computer system for testing of monitoring and/or treatment strategies for diabetes using a computer simulation environment, said testing method of said computer program logic comprising: representation of the human metabolic system, wherein said representation of the human metabolic system comprises: applying a mathematical model of the human metabolic system; and providing a plurality of instances of a simulated subject, creating a simulated population. |
| Current U.S. Class: |
702/19 |
| Current International Class: |
06; 01 |
| رقم الانضمام: |
edspap.20100179768 |
| قاعدة البيانات: |
USPTO Patent Applications |
