دورية أكاديمية
Erythropoiesis and renal transplant pregnancy.
| العنوان: | Erythropoiesis and renal transplant pregnancy. |
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| المؤلفون: | Magee, L. A., von Dadelszen, P., Darley, J., Beguin, Yves |
| المصدر: | Clinical Transplantation, 14 (2), 127-35 (2000) |
| بيانات النشر: | Blackwell Publishing, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Anemia/etiology, Case-Control Studies, Cohort Studies, Creatinine/blood, Erythropoiesis/physiology, Erythropoietin/blood, Female, Ferritins/blood, Folic Acid/blood, Gestational Age, Hemoglobins/analysis, Humans, Hypertension/etiology, Immunosuppressive Agents/therapeutic use, Kidney Transplantation/physiology, Linear Models, Parity, Pre-Eclampsia/etiology, Pregnancy/blood, Pregnancy Complications, Cardiovascular, Pregnancy Complications, Hematologic, Receptors, Transferrin/blood, Retrospective Studies, Time Factors, Vitamin B 12/blood, Human health sciences, Hematology, Sciences de la santé humaine, Hématologie |
| الوصف: | OBJECTIVE: To examine erythropoiesis in renal transplant pregnancies. METHODS: Retrospective cohort study of 30 renal transplant cases and 30 age, smoking and parity-matched healthy controls with normal index pregnancy. Retrospective chart review and assay of frozen antenatal serum (for serum erythropoietin concentration [serum EPO]), transferrin receptor protein [TfR], ferritin, folate and B12) were performed. The linear regression equation for normal pregnancy controls was used to calculate predicted [serum EPO] and the observed/predicted (O/P) log [serum EPO] was plotted. The relationship between [serum EPO] and haemoglobin (Hb) among transplant cases was considered to be different from that among controls if the slope of the O/P log [serum EPO] versus Hb regression was significantly different from zero. RESULTS: The transplant (14 cadaveric) to conception interval was (median [range]) 33.5 [4, 189] months. Immunosuppressants were azathioprine (n = 25), cyclosporine (n = 22) and/or prednisone (n = 25). Cases were more often primiparous (20 vs. 7 [controls]; p = 0.01), had pre-existent hypertension (20 vs. 0 [controls]; p < 0.001), developed new/increased hypertension or pre-eclampsia (28 vs. 0 [controls]; p < 0.001) and an antenatal rise in creatinine (14 vs. 2 [controls]; p < 0.001). In early pregnancy, cases had similar EPO (15.2 [2.6, 84.6] vs. 15.7 [6.4, 41.0] [controls] U/L) but lower Hb (101 [65, 129] vs. 116 [106, 150] g/L; p < 0.001). Twenty-two (73%) cases had Hb < 100 g/L (vs. 4 [controls]; p < 0.0001); Hb was comparable at 6 wk postpartum. With advancing gestational age (GA), Hb remained stable and serum EPO increased in both groups. The slope of the O/P log [serum EPO] versus Hb for transplant cases was significantly different from zero within both the 17-28 wk (slope +/- SEM: 0.010 +/- 0.002; p < 0.0001) and the 29-42 wk GA categories (0.006 +/- 0.003; p = 0.02). Cases showed smaller rises in serum TfR (change 481 [- 1471, 2780]) vs. 1119 [- 698, 4195] [controls] ng/mL; p = 0.005). CONCLUSIONS: Anaemia frequently complicates renal transplant pregnancies, in which serum EPO is inappropriately low and the rate of erythropoiesis blunted. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | urn:issn:0902-0063; urn:issn:1399-0012 |
| DOI: | 10.1034/j.1399-0012.2000.140205.x |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/8043Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.8043 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1034/j.1399-0012.2000.140205.x |
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