دورية أكاديمية
Coupling of cell migration with neurogenesis by proneural bHLH factors.
| العنوان: | Coupling of cell migration with neurogenesis by proneural bHLH factors. |
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| المؤلفون: | Ge, Weihong, He, Fei, Kim, Kevin J., Blanchi, Bruno, Coskun, Volkan, Nguyen, Laurent, Wu, Xiangbing, Zhao, Jing, Heng, Julian Ik-Tsen, Martinowich, Keri, Tao, Jifang, Wu, Hao, Castro, Diogo, Sobeih, Magdi M., Corfas, Gabriel, Gleeson, Joseph G., Greenberg, Michael E., Guillemot, François, Sun, Yi E. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America, 103 (5), 1319-24 (2006) |
| بيانات النشر: | National Academy of Sciences, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Actins/chemistry, Animals, Basic Helix-Loop-Helix Transcription Factors/metabolism, Blotting, Western, Cell Differentiation, Cell Movement, Cerebral Cortex/pathology, Chromatin Immunoprecipitation, Cytoskeleton/metabolism, DNA/chemistry, DNA-Binding Proteins/chemistry/physiology, Down-Regulation, Electroporation, GTP Phosphohydrolases/metabolism, Gene Expression Regulation, Mice, Mice, Transgenic, Microscopy, Fluorescence, Microtubule-Associated Proteins/biosynthesis, Microtubules/metabolism, Mutation, Nerve Tissue Proteins/biosynthesis/metabolism, Neurons/metabolism, Neuropeptides/biosynthesis, Protein Binding, Reverse Transcriptase Polymerase Chain Reaction, Transcription Factors/chemistry/physiology, Transfection, Up-Regulation, rhoA GTP-Binding Protein/metabolism, Life sciences, Anatomy (cytology, histology, embryology...) & physiology, Biochemistry, biophysics & molecular biology, Sciences du vivant, Anatomie (cytologie, histologie, embryologie...) & physiologie, Biochimie, biophysique & biologie moléculaire |
| الوصف: | After cell birth, almost all neurons in the mammalian central nervous system migrate. It is unclear whether and how cell migration is coupled with neurogenesis. Here we report that proneural basic helix-loop-helix (bHLH) transcription factors not only initiate neuronal differentiation but also potentiate cell migration. Mechanistically, proneural bHLH factors regulate the expression of genes critically involved in migration, including down-regulation of RhoA small GTPase and up-regulation of doublecortin and p35, which, in turn, modulate the actin and microtubule cytoskeleton assembly and enable newly generated neurons to migrate. In addition, we report that several DNA-binding-deficient proneural genes that fail to initiate neuronal differentiation still activate migration, whereas a different mutation of a proneural gene that causes a failure in initiating cell migration still leads to robust neuronal differentiation. Collectively, these data suggest that transcription programs for neurogenesis and migration are regulated by bHLH factors through partially distinct mechanisms. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | urn:issn:0027-8424; urn:issn:1091-6490 |
| DOI: | 10.1073/pnas.0510419103 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/4936Test |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ecTest info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsorb.4936 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1073/pnas.0510419103 |
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