دورية أكاديمية
Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection.
| العنوان: | Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection. |
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| المؤلفون: | Selinger, Christian, Rahmoun, Massilva, Murall, Carmen Lia, Bernat, Claire, Boué, Vanina, Bonneau, Marine, Graf, Christelle, Grasset, Sophie, Groc, Soraya, Reynes, Jacques, Hirtz, Christophe, Jacobs, Nathalie, Alizon, Samuel |
| المصدر: | Immunologic Research, 69 (3), 255-263 (2021-06) |
| بيانات النشر: | Springer, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cytokines, Human papillomavirus, Mucosal immunity, Natural history, IL1A protein, human, Interleukin-12 Subunit p40, Interleukin-1alpha, Adolescent, Adult, Alphapapillomavirus/immunology, Alphapapillomavirus/isolation & purification, Cervix Uteri/immunology, Cervix Uteri/metabolism, Cervix Uteri/virology, Female, Humans, Interleukin-12 Subunit p40/analysis, Interleukin-12 Subunit p40/metabolism, Interleukin-1alpha/analysis, Interleukin-1alpha/metabolism, Longitudinal Studies, Macrophages/immunology, Macrophages/metabolism, Papillomavirus Infections/blood, Papillomavirus Infections/immunology, Papillomavirus Infections/virology, Vagina/immunology, Vagina/metabolism, Vagina/virology, Young Adult, Alphapapillomavirus, Cervix Uteri, Macrophages, Papillomavirus Infections, Vagina, Immunology, Human health sciences, Immunology & infectious disease, Sciences de la santé humaine, Immunologie & maladie infectieuse |
| الوصف: | Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | https://link.springer.com/content/pdf/10.1007/s12026-021-09196-2.pdfTest; urn:issn:0257-277X; urn:issn:1559-0755 |
| DOI: | 10.1007/s12026-021-09196-2 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/292282Test |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ecTest info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsorb.292282 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1007/s12026-021-09196-2 |
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