دورية أكاديمية
Effect of nateglinide on the incidence of diabetes and cardiovascular events.
| العنوان: | Effect of nateglinide on the incidence of diabetes and cardiovascular events. |
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| المؤلفون: | Holman, Rury R, Haffner, Steven M, McMurray, John J, Bethel, M Angelyn, Holzhauer, Bjorn, Hua, Tsushung A, Belenkov, Yuri, Boolell, Mitradev, Buse, John B, Buckley, Brendan M, Chacra, Antonio R, Chiang, Fu*-Tien, Charbonnel, Bernard, Chow, Chun*-Chung, Davies, Melanie J, Deedwania, Prakash, Diem, Peter, Einhorn, Daniel, Fonseca, Vivian, Fulcher, Gregory R, Gaciong, Zbigniew, Gaztambide, Sonia, Giles, Thomas, Horton, Edward, Ilkova, Hasan, Jenssen, Trond, Kahn, Steven E, Krum, Henry, Laakso, Markku, Leiter, Lawrence A, Levitt, Naomi S, Mareev, Viacheslav, Martinez, Felipe, Masson, Chantal, Mazzone, Theodore, Meaney, Eduardo, Nesto, Richard, Pan, Changyu, Prager, Rudolf, Raptis, Sotirios A, Rutten, Guy E H M, Sandstroem, Herbert, Schaper, Frank, Scheen, André, Schmitz, Ole, Sinay, Isaac, Soska, Vladimir, Stender, Steen, Tamas, Gyula, Tognoni, Gianni, Tuomilehto, Jaako, Villamil, Alberto S, Vozar, Juraj, Califf, Robert M |
| المصدر: | New England Journal of Medicine, 362 (16), 1463-76 (2010) |
| بيانات النشر: | Massachusetts Medical Society, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Angiotensin II Type 1 Receptor Blockers/therapeutic use, Blood Glucose/analysis/drug effects, Body Weight/drug effects, Cardiovascular Diseases/epidemiology/mortality/prevention & control, Cyclohexanes/adverse effects/therapeutic use, Diabetes Mellitus, Type 2/epidemiology/prevention & control, Double-Blind Method, Drug Therapy, Combination, Exercise, Female, Follow-Up Studies, Glucose Intolerance/diet therapy/drug therapy/therapy, Humans, Hypoglycemic Agents/adverse effects/therapeutic use, Incidence, Kaplan-Meiers Estimate, Male, Middle Aged, Phenylalanine/adverse effects/analogs & derivatives/therapeutic use, Proportional Hazards Models, Risk Factors, Tetrazoles/therapeutic use, Treatment Failure, Valine/analogs & derivatives/therapeutic use, Human health sciences, Endocrinology, metabolism & nutrition, Cardiovascular & respiratory systems, Pharmacy, pharmacology & toxicology, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition, Systèmes cardiovasculaire & respiratoire, Pharmacie, pharmacologie & toxicologie |
| الوصف: | BACKGROUND: The ability of short-acting insulin secretagogues to reduce the risk of diabetes or cardiovascular events in people with impaired glucose tolerance is unknown. METHODS: In a double-blind, randomized clinical trial, we assigned 9306 participants with impaired glucose tolerance and either cardiovascular disease or cardiovascular risk factors to receive nateglinide (up to 60 mg three times daily) or placebo, in a 2-by-2 factorial design with valsartan or placebo, in addition to participation in a lifestyle modification program. We followed the participants for a median of 5.0 years for incident diabetes (and a median of 6.5 years for vital status). We evaluated the effect of nateglinide on the occurrence of three coprimary outcomes: the development of diabetes; a core cardiovascular outcome that was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure; and an extended cardiovascular outcome that was a composite of the individual components of the core composite cardiovascular outcome, hospitalization for unstable angina, or arterial revascularization. RESULTS: After adjustment for multiple testing, nateglinide, as compared with placebo, did not significantly reduce the cumulative incidence of diabetes (36% and 34%, respectively; hazard ratio, 1.07; 95% confidence interval [CI], 1.00 to 1.15; P=0.05), the core composite cardiovascular outcome (7.9% and 8.3%, respectively; hazard ratio, 0.94, 95% CI, 0.82 to 1.09; P=0.43), or the extended composite cardiovascular outcome (14.2% and 15.2%, respectively; hazard ratio, 0.93, 95% CI, 0.83 to 1.03; P=0.16). Nateglinide did, however, increase the risk of hypoglycemia. CONCLUSIONS: Among persons with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors, assignment to nateglinide for 5 years did not reduce the incidence of diabetes or the coprimary composite cardiovascular outcomes. (ClinicalTrials.gov number, NCT00097786.) |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | http://www.nejm.orgTest; urn:issn:0028-4793; urn:issn:1533-4406 |
| DOI: | 10.1056/NEJMoa1001122 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/25946Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.25946 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1056/NEJMoa1001122 |
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