دورية أكاديمية
Oral vitamin C reduces the injury to skeletal muscle caused by compartment syndrome.
| العنوان: | Oral vitamin C reduces the injury to skeletal muscle caused by compartment syndrome. |
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| المؤلفون: | Kearns, S. R., Daly, Adrian, Sheehan, K., Murray, P., Kelly, C., Bouchier-Hayes, D. |
| المصدر: | Journal of Bone and Joint Surgery, British Volume, 86 (6), 906-11 (2004) |
| بيانات النشر: | British Editorial Society of Bone and Joint Surgery, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Administration, Oral, Animals, Ascorbic Acid/administration & dosage, Compartment Syndromes/complications/enzymology, Edema, Intercellular Adhesion Molecule-1/metabolism, Muscle, Skeletal/blood supply/enzymology, Peroxidase/metabolism, Rats, Rats, Sprague-Dawley, Reperfusion Injury/enzymology/prevention & control, Human health sciences, Orthopedics, rehabilitation & sports medicine, Immunology & infectious disease, Sciences de la santé humaine, Orthopédie, rééducation & médecine sportive, Immunologie & maladie infectieuse |
| الوصف: | Compartment syndrome is a unique form of ischaemia of skeletal muscle which occurs despite patency of the large vessels. Decompression allows the influx of activated leucocytes which cause further injury. Vitamin C is a powerful antioxidant which concentrates preferentially in leucocytes and attenuates reperfusion-induced muscle injury. We have evaluated the use of pretreatment with oral vitamin C in the prevention of injury caused by compartment syndrome in a rat cremasteric muscle model. Acute and delayed effects of pretreatment with vitamin C were assessed at one and 24 hours after decompression of compartment syndrome. Muscle function was assessed electrophysiologically. Vascular, cellular and tissue inflammation was assessed by staining of intercellular adhesion molecule-1 (ICAM-1) and by determination of the activity of myeloperoxidase (MPO) in neutrophils and tissue oedema. Compartment syndrome impaired skeletal muscle function and increased the expression of ICAM-1, activity of MPO and muscle weight increased significantly. Pretreatment with vitamin C preserved muscle function and reduced the expression of ICAM-1, infiltration of the neutrophils and oedema. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| DOI: | 10.1302/0301-620X.86B6.14177 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/155141Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.155141 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1302/0301-620X.86B6.14177 |
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