دورية أكاديمية
Continuous subcutaneous insulin infusion with short-acting insulin analogues or human regular insulin: efficacy, safety, quality of life, and cost-effectiveness.
| العنوان: | Continuous subcutaneous insulin infusion with short-acting insulin analogues or human regular insulin: efficacy, safety, quality of life, and cost-effectiveness. |
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| المؤلفون: | Radermecker, Régis, Scheen, André |
| المصدر: | Diabetes/Metabolism Research and Reviews, 20 (3), 178-88 (2004) |
| بيانات النشر: | John Wiley & Sons, Inc, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Cost-Benefit Analysis, Diabetes Mellitus, Type 1/drug therapy, Economics, Female, Humans, Insulin/administration & dosage/analogs & derivatives, Insulin Infusion Systems/adverse effects, Pregnancy, Pregnancy in Diabetics/drug therapy, Quality of Life, Randomized Controlled Trials as Topic, Human health sciences, Endocrinology, metabolism & nutrition, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition |
| الوصف: | Portable insulin infusion devices are effective and safe insulin delivery systems for managing diabetes mellitus, especially type 1 diabetes. Rapidly absorbed insulin analogues, such as insulin lispro or insulin aspart, may offer an advantage over regular human insulin for insulin pumps. Several open-label randomised crossover trials demonstrated that continuous subcutaneous insulin infusion (CSII) with insulin lispro provided a better control of postprandial hyperglycaemia and a slightly but significantly lower glycated haemoglobin level, with lower daily insulin requirement and similar or even less hypoglycaemic episodes. A CSII study comparing insulin lispro and insulin aspart demonstrated similar results with the two analogues, and better results than those with regular insulin. Because these analogues have a quicker onset and a shorter duration of action than regular insulin, one might expect an earlier and greater metabolic deterioration in case of CSII interruption, but a more rapid correction of metabolic abnormalities after insulin boluses when reactivating the pump. These expectations were confirmed in randomised protocols comparing the metabolic changes occurring during and after CSII interruption of various durations when the pump infused either insulin lispro or regular insulin. The extra cost resulting from the use of CSII and insulin analogues in diabetes management should be compensated for by better metabolic control and quality of life. In conclusion, CSII delivering fast-acting insulin analogues may be considered as one of the best methods to replace insulin in a physiological manner by mimicking meal and basal insulin requirements, without higher risk of hypoglycaemia or ketoacidosis in well-educated diabetic patients. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | urn:issn:1520-7552; urn:issn:1520-7560 |
| DOI: | 10.1002/dmrr.447 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/15013Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.15013 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1002/dmrr.447 |
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