دورية أكاديمية
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
| العنوان: | Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle. |
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| المؤلفون: | Sandor, Cynthia, Li, Wanbo, Coppieters, Wouter, Druet, Tom, Charlier, Carole, Georges, Michel |
| المصدر: | PLoS Genetics, 8 (7), e1002854 (2012) |
| بيانات النشر: | Public Library of Science, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Animals, Cattle, Cell Cycle Proteins/genetics, Chromosome Mapping, Crossing Over, Genetic, Genetic Linkage, Genome, Histone-Lysine N-Methyltransferase/genetics, Homologous Recombination/genetics, Humans, Male, Miosis/genetics, Pedigree, Polymorphism, Single Nucleotide, Quantitative Trait Loci/genetics, Sequence Homology, Amino Acid, Sperm Count, Spermatozoa/cytology, Ubiquitin-Protein Ligases/genetics, Life sciences, Genetics & genetic processes, Sciences du vivant, Génétique & processus génétiques |
| الوصف: | We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article |
| اللغة: | English |
| العلاقة: | urn:issn:1553-7390; urn:issn:1553-7404 |
| DOI: | 10.1371/journal.pgen.1002854 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/138747Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.138747 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1371/journal.pgen.1002854 |
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