مورد إلكتروني
Impact of early nausea on varenicline adherence and smoking cessation.
| العنوان: | Impact of early nausea on varenicline adherence and smoking cessation. |
|---|---|
| المؤلفون: | Ahluwalia, Jasjit |
| المصدر: | Addiction; vol 115, iss 1 |
| بيانات النشر: | eScholarship, University of California 2020-01-01 |
| تفاصيل مُضافة: | Ahluwalia, Jasjit Lerman, Caryn Nollen, Nicole Tyndale, Rachel Peng, Annie Swardfager, Walter Benowitz, Neal |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND AND AIMS: Varenicline effectiveness may be related to the level of adherence, which might be reduced by adverse effects such as nausea. The aim of the study was to test a possible effect of nausea on smoking cessation outcomes mediated by adherence. DESIGN: Mediation path analysis. SETTING: Multiple sites within Canada and the United States. PARTICIPANTS: Treatment-seeking smokers receiving varenicline from two smoking cessation clinical trials: Quit2Live (NCT01836276; n = 449) and Pharmacogenetics of Nicotine Addiction Treatment (PNAT) (NCT01314001; n = 421). MEASUREMENTS: Nausea severity was collected through self-report and adherence was biologically assessed using varenicline concentrations (Quit2Live, plasma sample at week 4; PNAT, saliva sample at week 2). In Quit2Live, the end-points were cotinine-verified abstinence at weeks 4, 12 and 26. In PNAT, the end-points were carbon monoxide-verified abstinence at weeks 2, 12 and 26. FINDINGS: Early nausea was not directly associated with abstinence [odds ratio (OR) ranging from 0.73-1.28; P ≥ 0.26]. However early nausea was indirectly associated with lower cessation rates at multiple timepoints (ORs ranging from 0.92-0.94; 95% CI between 0.83-0.99) in a relationship mediated by reduced varenicline adherence (assessed by plasma varenicline concentrations) in the primary trial (Quit2Live). This relationship between nausea, adherence and cessation was similar in direction but weaker in effect size (ORs ranging from 0.98-0.99; 95% CI between 0.90-1.03) in a secondary trial (PNAT), where adherence was assessed using salivary varenicline concentrations. CONCLUSIONS: These data suggest that early nausea during varenicline treatment may be indirectly associated with lower likelihood of smoking cessation through reducing varenicline adherence. Differences in robustness between the trials may be due to the different biological matrices (plasma vs. saliva) and/or timing used to assess varenicline |
| مصطلحات الفهرس: | Adherence, adverse events, compliance, nausea, smoking cessation, varenicline, Adult, Canada, Female, Humans, Male, Mediation Analysis, Medication Adherence, Middle Aged, Nausea, Smoking Cessation, Smoking Cessation Agents, United States, Varenicline, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Addiction vol 115, iss 1 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt5wt6w4qs qt5wt6w4qs https://escholarship.org/uc/item/5wt6w4qsTest https://escholarship.orgTest/ 1410329803 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1410329803 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |