مورد إلكتروني
Comparison of clinical features between patients with acute exacerbation of idiopathic interstitial pneumonia and collagen vascular disease-associated interstitial pneumonia
| العنوان: | Comparison of clinical features between patients with acute exacerbation of idiopathic interstitial pneumonia and collagen vascular disease-associated interstitial pneumonia |
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| بيانات النشر: | Nagoya University Graduate School of Medicine, School of Medicine 2023-08 |
| تفاصيل مُضافة: | Kata, Yuki Hara, Yu Murohashi, Kota Saigusa, Yusuke Nagasawa, Ryo Tagami, Yoichi Fujii, Hiroaki Aoki, Ayako Nishikawa, Yurika Tanaka, Katsushi Watanabe, Keisuke Horita, Nobuyuki Kobayashi, Nobuaki Yamamoto, Masaki Kudo, Makoto Kaneko, Takeshi |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Acute exacerbation (AE) of interstitial pneumonia (IP) shows poor prognosis, due to the typical histological pattern of diffuse alveolar damage superimposed upon lung fibrosis. The previous reports comparing clinical features between AE of idiopathic interstitial pneumonias (IIPs) and those of IPs with known etiology are limited. We retrospectively compared clinical parameters including age, sex, Charlson Comorbidity Index score (CCIS), blood biomarkers at diagnosis of AE, treatment, and 3-month mortality between patients with AE of IIPs and collagen vascular disease-associated interstitial pneumonia (CVD-IP). We assessed 85 patients, comprising 66 patients with AE of IIPs (78%) and 19 patients with AE of CVD-IP (22%). The least absolute shrinkage and selection operator regression selected CCIS (hazard ratio, 1.281; 95% confidence interval, 1.055–1.556; P = 0.012) and log serum lactate dehydrogenase (LDH) (hazard ratio, 6.267; 95% confidence interval, 2.172–18.085; P < 0.001) as significant predictors of 3-month mortality among these patients. Also, the adjusted survival curves using sex, CCIS, and serum LDH showed no significant differences between these two groups. In conclusion, among AE patients, CCIS and serum LDH level may be more important prognostic factors for 3-month mortality rather than two classification of IP subtypes: IIPs and CVD-IP. |
| مصطلحات الفهرس: | acute exacerbation, Charlson Comorbidity Index score, collagen vascular disease-associated interstitial pneumonia, idiopathic interstitial pneumonia, lactate dehydrogenase, Departmental Bulletin Paper, VoR |
| URL: | |
| الإتاحة: | Open access content. Open access content open access Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | JPNII oai:irdb.nii.ac.jp:01152:0005896219 0027-7622 2186-3326 Nagoya Journal of Medical Science, 85(3), 602-611 1409766944 |
| المصدر المساهم: | NATIONAL INST OF INFO From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1409766944 |
| قاعدة البيانات: | OAIster |
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