مورد إلكتروني
Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes
| العنوان: | Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes |
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| المصدر: | Cangemi , C , Skov , V , Poulsen , M K , Funder , J , Twal , W O , Gall , M-A , Hjortdal , V , Jespersen , M L , Kruse , T A , Aagard , J , Parving , H-H , Knudsen , S , Høilund-Carlsen , P-F , Rossing , P , Henriksen , J E , Argraves , W S & Rasmussen , L M 2011 , ' Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes ' , Clinical Chemistry , vol. 57 , no. 11 , pp. 1556-65 . |
| بيانات النشر: | 2011-11 |
| تفاصيل مُضافة: | Cangemi, Claudia Skov, Vibe Poulsen, Michael Kjaer Funder, Jonas Twal, Waleed O Gall, Mari-Anne Hjortdal, Vibeke Jespersen, Marie Louise Kruse, Torben A Aagard, Jan Parving, Hans-Henrik Knudsen, Steen Høilund-Carlsen, Poul-Flemming Rossing, Peter Henriksen, Jan Erik Argraves, William Scott Rasmussen, Lars Melholt |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND: Extracellular matrix alterations are important elements in the arterial changes seen in diabetes, being associated with increased vascular stiffness and the development of cardiovascular diseases. However, no biomarkers for diabetes-related arterial changes have been defined.METHODS: Mammary artery specimens from 17 men with type 2 diabetes and 18 nondiabetic individuals were used for microarray expression profiling, quantitative real-time PCR, immunoassay, and immunohistochemical analyses. A derived candidate marker, fibulin-1, which is an elastin-associated matrix molecule, was measured immunochemically in plasma from (a) 70 patients scheduled for vascular surgery, (b) 305 patients with type 2 diabetes examined with carotid ultrasonography and echocardiography, and (c) 308 patients with type 2 diabetes, followed for 15 years.RESULTS: The most upregulated transcript in nonatherosclerotic arterial tissue from patients with type 2 diabetes encoded the extracellular matrix protein, fibulin-1. Higher concentrations of fibulin-1-protein were present in artery extracts from patients with diabetes than extracts from individuals without diabetes, and increased fibulin-1 immunostaining was apparent around the external elastic lamina of diabetic arteries. Patients with diabetes displayed increased plasma concentrations of fibulin-1 (P = 0.006). Plasma fibulin-1 concentrations correlated with hemoglobin A(1c) (P < 0.001), arterial stiffness indices including pulse pressure (P < 0.001), and carotid compliance (P = 0.004), as well as plasma N-terminal pro-B-type natriuretic peptide concentrations (P < 0.001) and were predictive of 15-year mortality (P = 0.013).CONCLUSIONS: Fibulin-1 accumulates in the arterial wall and in plasma of patients with type 2 diabetes, and appears to be a factor associated with arterial extracellular matrix changes in type 2 diabetes. |
| مصطلحات الفهرس: | Aged, Biomarkers/metabolism, Calcium-Binding Proteins/blood, Cardiovascular Diseases/diagnosis, Carotid Intima-Media Thickness, Case-Control Studies, Diabetes Mellitus, Type 2/complications, Extracellular Matrix/metabolism, Extracellular Matrix Proteins/metabolism, Female, Follow-Up Studies, Humans, Immunoassay, Immunohistochemistry, Male, Mammary Arteries/metabolism, Middle Aged, Oligonucleotide Array Sequence Analysis, Predictive Value of Tests, Prospective Studies, Real-Time Polymerase Chain Reaction, article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | DAV oai:pure.atira.dk:publications/29539e9d-8522-4548-b206-909d5348c2c3 1408252083 |
| المصدر المساهم: | UNIV OF COPENHAGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1408252083 |
| قاعدة البيانات: | OAIster |
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