مورد إلكتروني
Pemphigoid diseases affecting the skin
| العنوان: | Pemphigoid diseases affecting the skin |
|---|---|
| المصدر: | Meijer , J M , Lamberts , A & Terra , J B 2022 , Pemphigoid diseases affecting the skin . in Autoimmune Bullous Diseases : Text and Review . Springer International Publishing AG , pp. 107-120 . |
| بيانات النشر: | Springer International Publishing AG 2022-01-19 |
| تفاصيل مُضافة: | Meijer, Joost M. Lamberts, Aniek Terra, Jorrit B. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Pemphigoid diseases are a heterogeneous group of subepidermal autoimmune blistering diseases (sAIBD) that are characterized by autoantibodies against different structural proteins of hemidesmosomes in the epidermal basement membrane zone (EBMZ). The group of pemphigoid diseases affecting the skin include various subtypes, such as bullous pemphigoid (BP), nonbullous pemphigoid (NBP), Brunsting-Perry cicatricial pemphigoid, lichen planus pemphigoides (LPP), pemphigoid gestationis (PG), and anti-p200 pemphigoid. Classification of sAIBD subtypes is mainly based on target antigens and/or clinical manifestations. Pathogenesis of pemphigoid diseases is mediated by predominantly IgG autoantibodies against different structural proteins in the EBMZ. Diagnosis is based on a combination of clinical features, an n-serrated linear pattern of immunodepositions along the EBMZ in direct immunofluorescence microscopy and immunoserology. BP is the most common subtype and most frequently affects elderly, the incidence of BP increased substantially in the past decades. The clinical manifestations of pemphigoid diseases are heterogeneous and represent a clinical spectrum. The typical presentation of BP is a severe pruritus with a predominantly cutaneous lesions consisting of tense blisters or vesicles, erythema and urticarial plaques. In NBP blistering is absent, while the pruritus is severe, and erythematous papules, plaques and excoriations may mimick other inflammatory dermatoses. Recommended therapies consists of whole-body application of superpotent topical corticosteroids, or systemic treatment with immunosuppressive or -modulating drugs. |
| مصطلحات الفهرس: | Autoimmune disease, Basement membrane zone, Bullous Pemphigoid, Hemidesmosome, Immunoglobuline, Nonbullous Pemphigoid, Vesiculo-bullous disease, bookPart |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | GRU oai:pure.rug.nl:publications/a2f1fdee-1208-48c3-b1df-ac061a80a07d urn:ISBN:9783030915568 1407408988 |
| المصدر المساهم: | UNIV OF GRONINGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1407408988 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |