مورد إلكتروني
Insights into immune tolerance from AIRE deficiency.
| العنوان: | Insights into immune tolerance from AIRE deficiency. |
|---|---|
| المؤلفون: | Proekt, Irina |
| بيانات النشر: | eScholarship, University of California 2017-12-01 |
| تفاصيل مُضافة: | Proekt, Irina Miller, Corey N Lionakis, Michail S Anderson, Mark S |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | AIRE is a well-established master regulator of central tolerance. It plays an essential role in driving expression of tissue-specific antigens in the thymus and shaping the development of positively selected T-cells. Humans and mice with compromised or absent AIRE function have markedly variable phenotypes that include a range of autoimmune manifestations. Recent evidence suggests that this variability stems from cooperation of autoimmune susceptibilities involving both central and peripheral tolerance checkpoints. Here we discuss the broadening understanding of the factors that influence Aire expression, modify AIRE function, and the impact and intersection of AIRE with peripheral immunity. This rapidly expanding body of knowledge will force a reexamination of the definition and clinical management of APS-1 patients as well as provide a foundation for the development of immunomodulatory strategies targeting central tolerance. |
| مصطلحات الفهرس: | Thymus Gland, Animals, Humans, Mice, Polyendocrinopathies, Autoimmune, Transcription Factors, Autoantigens, Immune Tolerance, Gene Expression Regulation, Phenotype, Autoimmune Disease, Underpinning research, 1.1 Normal biological development and functioning, Inflammatory and immune system, Immunology, publication |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt4z31r6kz qt4z31r6kz https://escholarship.org/uc/item/4z31r6kzTest https://escholarship.orgTest/ 1391606512 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391606512 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |