مورد إلكتروني
Total Syntheses of Xiamycins A, C, F, H and Oridamycin A and Preliminary Evaluation of their Anti-Fungal Properties.
| العنوان: | Total Syntheses of Xiamycins A, C, F, H and Oridamycin A and Preliminary Evaluation of their Anti-Fungal Properties. |
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| المؤلفون: | Pfaffenbach, Magnus |
| المصدر: | Angewandte Chemie (International ed. in English); vol 58, iss 43, 15304-15308; 1433-7851 |
| بيانات النشر: | eScholarship, University of California 2019-10-01 |
| تفاصيل مُضافة: | Pfaffenbach, Magnus Bakanas, Ian O'Connor, Nicholas R Herrick, Jessica L Sarpong, Richmond |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Divergent and enantiospecific total syntheses of the indolosesquiterpenoids xiamycins A, C, F, H and oridamycin A have been accomplished. The syntheses, which commence from (R)-carvone, employ a key photoinduced benzannulation sequence to forge the carbazole moiety characteristic of these natural products. Late-stage diversification from a common intermediate enabled the first syntheses of xiamycins C and F, and an unexpected one-pot oxidative decarboxylation, which may prove general, led to xiamycin H. All synthetic intermediates and the natural products were tested for anti-fungal activity. Xiamycin H emerged as an inhibitor of three agriculturally relevant fungal pathogens. |
| مصطلحات الفهرس: | Ustilago, Mitosporic Fungi, Sesquiterpenes, Antifungal Agents, Cyclization, Decarboxylation, Oxidation-Reduction, Stereoisomerism, Light, Cyclohexane Monoterpenes, benzannulation, chiral pool, divergent synthesis, fungitoxicity, total synthesis, Infectious Diseases, Infection, Chemical Sciences, Organic Chemistry, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Angewandte Chemie (International ed. in English) vol 58, iss 43, 15304-15308 1433-7851 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt8b0860s6 qt8b0860s6 https://escholarship.org/uc/item/8b0860s6Test https://escholarship.orgTest/ 1391604090 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391604090 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |