مورد إلكتروني
Multi-domain neurocognitive classification of primary brain tumor patients prior to radiotherapy on a prospective clinical trial.
| العنوان: | Multi-domain neurocognitive classification of primary brain tumor patients prior to radiotherapy on a prospective clinical trial. |
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| المؤلفون: | Karunamuni, Roshan |
| المصدر: | Journal of neuro-oncology; vol 146, iss 1, 131-138; 0167-594X |
| بيانات النشر: | eScholarship, University of California 2020-01-01 |
| تفاصيل مُضافة: | Karunamuni, Roshan Tringale, Kathryn R Burkeen, Jeffrey Tibbs, Michelle D Huynh-Le, Minh-Phuong Bahrami, Naeim Marshall, Deborah Seibert, Tyler M McDonald, Carrie R Hattangadi-Gluth, Jona A |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | IntroductionWe investigated multi-domain baseline neurocognition of primary brain tumor patients prior to radiotherapy (RT), including clinical predictors of function and association between pre-RT and post-RT impairment on a prospective trial.MethodsA multi-domain neuropsychological battery (memory, executive functioning, language, attention, processing) was performed on 37 patients, pre-RT and 3-(n = 21), 6-(n = 22) and 12-(n = 14) months post-RT. Impairment rate was the proportion of patients with standardized T-scores ≤ 1.5 standard deviations below normative means. Per-patient impairment across all domains was calculated using a global deficit score (GDS; higher value indicates more impairment). Associations between baseline GDS and clinical variables were tested. Global GDS impairment rate at each time point was the fraction of patients with GDS scores > 0.5.ResultsStatistically significant baseline neurocognitive impairments were identified on 4 memory (all p ≤ 0.03) and 2 out of 3 (p = 0.01, p = 0.027) executive functioning tests. Per-patient baseline GDS was significantly associated with tumor volume (p = 0.048), tumor type (p = 0.043), seizure history (p = 0.007), and use of anti-epileptics (p = 0.009). The percentage of patients with the same impairment status at 3-, 6-, and 12-months as at baseline were 88%, 85%, and 85% respectively.ConclusionsMemory and executive functioning impairment were the most common cognitive deficits prior to RT. Patients with larger tumors, more aggressive histology, and use of anti-epileptics had higher baseline GDS values. GDS is a promising tool to encompass multi-domain neurocognitive function, and baseline GDS can identify those at risk of cognitive impairment. |
| مصطلحات الفهرس: | Humans, Brain Neoplasms, Memory Disorders, Prognosis, Radiotherapy, Follow-Up Studies, Prospective Studies, Neuropsychological Tests, Adult, Middle Aged, Female, Male, Executive Function, Neurocognitive Disorders, Global deficit score, Neurocognitive function, Primary brain tumors, Cancer, Neurosciences, Clinical Research, Mental Health, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Behavioral and Social Science, Brain Disorders, Mental health, Oncology and Carcinogenesis, Oncology & Carcinogenesis, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Journal of neuro-oncology vol 146, iss 1, 131-138 0167-594X |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt9w72f1x1 qt9w72f1x1 https://escholarship.org/uc/item/9w72f1x1Test https://escholarship.orgTest/ 1391602538 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391602538 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |