مورد إلكتروني
Association of Low-Density Lipoprotein Testing After an Atherosclerotic Cardiovascular Event with Subsequent Statin Adherence and Intensification.
| العنوان: | Association of Low-Density Lipoprotein Testing After an Atherosclerotic Cardiovascular Event with Subsequent Statin Adherence and Intensification. |
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| المؤلفون: | Rana, Jamal S |
| المصدر: | The American journal of medicine; vol 135, iss 5, 603-606; 0002-9343 |
| بيانات النشر: | eScholarship, University of California 2022-05-01 |
| تفاصيل مُضافة: | Rana, Jamal S Virani, Salim S Moffet, Howard H Liu, Jennifer Y Coghlan, Landis A Vasadia, Jitesh Ballantyne, Christie M Karter, Andrew J |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | PurposeThis study aimed to evaluate associations between outpatient low-density lipoprotein cholesterol (LDL-C) testing and subsequent statin adherence and intensification in patients after an atherosclerotic cardiovascular (ASCVD) event.MethodsThis was a longitudinal study of adult members of Kaiser Permanente Northern California hospitalized with an ASCVD event (myocardial infarction or stroke) during January 01, 2016, to December 31, 2017, with follow-up through December 31, 2019. Outcomes were statin adherence (estimated using continuous medication gap [CMG]) and intensification (defined by an increased dose or switch to a higher-intensity statin) based on pharmacy dispensing. The exposure of interest was first outpatient LDL-C test after an ASCVD event. Baseline for follow-up was LDL-C test date or a date assigned using incidence density sampling. Multivariate logistic regression models were specified to estimate the odds ratios for statin adherence or intensification among those with vs without an LDL-C test, with adjustment for age, sex, race/ethnicity, smoking, hypertension, diabetes, body mass index, and estimated glomerular filtration rate.ResultsThere were 19,604 adults hospitalized with ASCVD, including 7054 adults not on high-intensity statins. The mean age was 69.5 years and 33.0% were female. Prevalence of good adherence (continuous medication gap ≤20%) was significantly higher (80.2% vs 75.9%; odds ratio 1.38; 95% confidence interval, 1.28-1.49; P <.001) among participants who had an LDL-C test compared with participants who did not. LDL-C testing was associated with significantly higher rates of treatment intensification (16.1% vs 10.7%; odds ratio 1.51; 95% confidence interval,1.29-1.76; P <0.001).ConclusionsLow-density lipoprotein cholesterol testing is recommended for patients with a history of ASCVD and may be a high-value and low-cost intervention to improve adherence and statin management. |
| مصطلحات الفهرس: | Humans, Cardiovascular Diseases, Myocardial Infarction, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Longitudinal Studies, Adult, Aged, Female, Male, Atherosclerosis, Cholesterol, LDL, Stroke, Medication Adherence, Cardiovascular disease, Low-density lipoprotein cholesterol, Low-density lipoprotein cholesterol testing, Clinical Research, Cardiovascular, Good Health and Well Being, Medical and Health Sciences, General & Internal Medicine, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf The American journal of medicine vol 135, iss 5, 603-606 0002-9343 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt5x88b5x8 qt5x88b5x8 https://escholarship.org/uc/item/5x88b5x8Test https://escholarship.orgTest/ 1391590921 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391590921 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |