مورد إلكتروني
AIRE expands: new roles in immune tolerance and beyond.
| العنوان: | AIRE expands: new roles in immune tolerance and beyond. |
|---|---|
| المؤلفون: | Anderson, Mark S |
| المصدر: | Nature reviews. Immunology; vol 16, iss 4, 247-258; 1474-1733 |
| بيانات النشر: | eScholarship, University of California 2016-04-01 |
| تفاصيل مُضافة: | Anderson, Mark S Su, Maureen A |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | More than 15 years ago, mutations in the autoimmune regulator (AIRE) gene were identified as the cause of autoimmune polyglandular syndrome type 1 (APS1). It is now clear that this transcription factor has a crucial role in promoting self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery. In this Review, we highlight many of the recent advances in our understanding of the complex biology that is related to AIRE, with a particular focus on advances in genetics, molecular interactions and the effect of AIRE on thymic selection of regulatory T cells. Furthermore, we highlight new areas of biology that are potentially affected by this key regulator of immune tolerance. |
| مصطلحات الفهرس: | Humans, Polyendocrinopathies, Autoimmune, Autoimmune Diseases, Transcription Factors, Autoantigens, Immune Tolerance, Self Tolerance, Mutation, T-Lymphocytes, Regulatory, Genetics, Autoimmune Disease, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Underpinning research, Inflammatory and immune system, Immunology, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Nature reviews. Immunology vol 16, iss 4, 247-258 1474-1733 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt73q6496d qt73q6496d https://escholarship.org/uc/item/73q6496dTest https://escholarship.orgTest/ 1378689249 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1378689249 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |