مورد إلكتروني
Sex and Gender Considerations in Episodic Migraine.
| العنوان: | Sex and Gender Considerations in Episodic Migraine. |
|---|---|
| المؤلفون: | Ahmad, Sarah R |
| المصدر: | Current pain and headache reports; vol 26, iss 7, 505-516; 1531-3433 |
| بيانات النشر: | eScholarship, University of California 2022-07-01 |
| تفاصيل مُضافة: | Ahmad, Sarah R Rosendale, Nicole |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Purpose of reviewWe seek to update readers on recent advances in our understanding of sex and gender in episodic migraine with a two part series. In part 1, we examine migraine epidemiology in the context of sex and gender, differences in symptomatology, and the influence of sex hormones on migraine pathophysiology (including CGRP). In part 2, we focus on practical clinical considerations for sex and gender in episodic migraine by addressing menstrual migraine and the controversial topic of hormone-containing therapies. We make note of data applicable to gender minority populations, when available, and summarize knowledge on gender affirming hormone therapy and migraine management in transgender individuals. Finally, we briefly address health disparities, socioeconomic considerations, and research bias.Recent findingsMigraine is known to be more prevalent, frequent, and disabling in women. There are also differences in migraine co-morbidities and symptomatology. For instance, women are likely to experience more migraine associated symptoms such as nausea, photophobia, and phonophobia. Migraine pathophysiology is influenced by sex hormones, e.g., estrogen withdrawal as a known trigger for migraine. Other hormones such as progesterone and testosterone are less well studied. Relationships between CGRP (the target of new acute and preventive migraine treatments) and sex hormones have been established with both animal and human model studies. The natural course of migraine throughout the lifetime suggests a contribution from hormonal changes, from puberty to pregnancy to menopause/post-menopause. Treatment of menstrual migraine and the use of hormone-containing therapies remains controversial. Re-evaluation of the data reveals that stroke risk is an estrogen dose- and aura frequency-dependent phenomenon. There are limited data on episodic migraine in gender minorities. Gender affirming hormone therapy may be associated with a change in migraine and unique risks (includin |
| مصطلحات الفهرس: | Humans, Gonadal Steroid Hormones, Calcitonin Gene-Related Peptide, Estrogens, Pregnancy, Menopause, Female, Male, Migraine Disorders, Stroke, CGRP, Episodic migraine, Gender, Gender minority, Sex, Sex hormones, Pain Research, Estrogen, Headaches, Contraception/Reproduction, Neurosciences, Aging, Brain Disorders, Chronic Pain, Migraines, Clinical Sciences, Pharmacology and Pharmaceutical Sciences, Neurology & Neurosurgery, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Current pain and headache reports vol 26, iss 7, 505-516 1531-3433 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt5z00d6rq qt5z00d6rq https://escholarship.org/uc/item/5z00d6rqTest https://escholarship.orgTest/ 1367459550 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1367459550 |
| قاعدة البيانات: | OAIster |
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