مورد إلكتروني
Association of lactate dehydrogenase with mortality in incident hemodialysis patients.
| العنوان: | Association of lactate dehydrogenase with mortality in incident hemodialysis patients. |
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| المؤلفون: | Ryu, Soh Young |
| المصدر: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association; vol 36, iss 4, 704-712; 0931-0509 |
| بيانات النشر: | eScholarship, University of California 2021-03-01 |
| تفاصيل مُضافة: | Ryu, Soh Young Kleine, Carola-Ellen Hsiung, Jui-Ting Park, Christina Rhee, Connie M Moradi, Hamid Hanna, Ramy Kalantar-Zadeh, Kamyar Streja, Elani |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BackgroundLactate dehydrogenase (LDH) plays a role in the glucose metabolism of the human body. Higher LDH levels have been linked to mortality in various cancer types; however, the relationship between LDH and survival in incident hemodialysis (HD) patients has not yet been examined. We hypothesized that higher LDH level is associated with higher death risk in these patients.MethodsWe examined the association of baseline and time-varying serum LDH with all-cause, cardiovascular and infection-related mortality among 109 632 adult incident HD patients receiving care from a large dialysis organization in the USA during January 2007 to December 2011. Baseline and time-varying survival models were adjusted for demographic variables and available clinical and laboratory surrogates of malnutrition-inflammation complex syndrome.ResultsThere was a linear association between baseline serum LDH levels and all-cause, cardiovascular and infection-related mortality in both baseline and time-varying models, except for time-varying infection-related mortality. Adjustment for markers of inflammation and malnutrition attenuated the association in all models. In fully adjusted models, baseline LDH levels ≥360 U/L were associated with the highest risk of all-cause mortality (hazard ratios = 1.19, 95% confidence interval 1.14-1.25). In time-varying models, LDH >280 U/L was associated with higher death risk in all three hierarchical models for all-cause and cardiovascular mortality.ConclusionsHigher LDH level >280 U/L was incrementally associated with higher all-cause and cardiovascular mortality in incident dialysis patients, whereas LDH <240 U/L was associated with better survival. These findings suggest that the assessment of metabolic functions and monitoring for comorbidities may confer survival benefit to dialysis patients. |
| مصطلحات الفهرس: | Humans, Cardiovascular Diseases, L-Lactate Dehydrogenase, Prognosis, Renal Dialysis, Survival Rate, Adult, Middle Aged, Female, Male, Biomarkers, Infections, all-cause mortality, end-stage renal disease, hemodialysis, lactate dehydrogenase, Bioengineering, Cardiovascular, Kidney Disease, Assistive Technology, Clinical Research, Zero Hunger, Good Health and Well Being, Clinical Sciences, Urology & Nephrology, article |
| URL: | |
| الإتاحة: | Open access content. Open access content CC-BY |
| ملاحظة: | application/pdf Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association vol 36, iss 4, 704-712 0931-0509 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt7m94r90z qt7m94r90z https://escholarship.org/uc/item/7m94r90zTest https://escholarship.orgTest/ 1367448251 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1367448251 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |