مورد إلكتروني
Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'.
| العنوان: | Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'. |
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| المؤلفون: | Landegren, Nils |
| بيانات النشر: | eScholarship, University of California 2019-06-01 |
| تفاصيل مُضافة: | Landegren, Nils Rosen, Lindsey B Freyhult, Eva Eriksson, Daniel Fall, Tove Smith, Gustav Ferre, Elise MN Brodin, Petter Sharon, Donald Snyder, Michael Lionakis, Michail Anderson, Mark Kämpe, Olle |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion. |
| مصطلحات الفهرس: | Humans, Diabetes Mellitus, Type 1, Polyendocrinopathies, Autoimmune, Interferon Type I, Transcription Factors, Autoantibodies, APS1/APECED, autoantibody, autoantigen, human, human biology, immune tolerance, immunology, inflammation, medicine, type 1 diabetes, Autoimmune Disease, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Biochemistry and Cell Biology, publication |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt4f06t02j qt4f06t02j https://escholarship.org/uc/item/4f06t02jTest https://escholarship.orgTest/ 1367407537 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1367407537 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |