مورد إلكتروني
The influence of nicotine metabolic rate on working memory over 6 hours of abstinence from nicotine.
| العنوان: | The influence of nicotine metabolic rate on working memory over 6 hours of abstinence from nicotine. |
|---|---|
| المؤلفون: | Nardone, Natalie |
| بيانات النشر: | eScholarship, University of California 2020-01-01 |
| تفاصيل مُضافة: | Nardone, Natalie Shahid, Marian Strasser, Andrew A Dempsey, Delia A Benowitz, Neal L |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BackgroundA faster rate of nicotine metabolism has been associated with smoking more cigarettes, greater nicotine withdrawal symptoms, and lower smoking quit rates. However, the association between nicotine metabolic rate (NMR) and cognitive functioning during withdrawal has not been determined.MethodsWe compared cognitive function in 121 fast or slow nicotine metabolizers after smoking, and at 3 and 6 h of nicotine abstinence. Cognitive functioning was assessed using N-back working memory tests with outcomes of accuracy and processing speed. Participants smoked two cigarettes and then abstained from smoking for 6 h. N-back tests were administered after smoking (0 h) and at 3 and 6 h of nicotine abstinence.ResultsAn effect of processing speed was found over time on the 2-back, in that participants had significantly longer average reaction times when the stimuli presented did not match the target letter. NMR was not significantly associated with the processing speed change over time. Within-race differences in working memory were evident in that Caucasian fast metabolizers had significantly poorer accuracy and processing speed.ConclusionsMinimal change in working memory over 6 h of nicotine abstinence was observed. Overall, NMR was not significantly associated with the change in processing speed, however Caucasian fast metabolizers displayed poorer accuracy and processing speed at discrete time points. |
| مصطلحات الفهرس: | Humans, Nicotine, Magnetic Resonance Spectroscopy, Prospective Studies, Smoking Cessation, Cognition, Memory, Short-Term, Reaction Time, Time Factors, Adult, Middle Aged, Female, Male, Young Adult, Cigarette Smoking, NMR, Nicotine metabolite ratio, Smoking, Working memory, Drug Abuse (NIDA Only), Tobacco Smoke and Health, Prevention, Tobacco, Substance Abuse, Mental health, Good Health and Well Being, Pharmacology and Pharmaceutical Sciences, Neurology & Neurosurgery, publication |
| URL: | |
| الإتاحة: | Open access content. Open access content CC-BY-NC-SA |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt9bm088x9 qt9bm088x9 https://escholarship.org/uc/item/9bm088x9Test https://escholarship.orgTest/ 1367404768 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1367404768 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |