مورد إلكتروني
The effect of sample size on polygenic hazard models for prostate cancer.
| العنوان: | The effect of sample size on polygenic hazard models for prostate cancer. |
|---|---|
| المؤلفون: | Karunamuni, Roshan A |
| المصدر: | European journal of human genetics : EJHG; vol 28, iss 10, 1467-1475; 1018-4813 |
| بيانات النشر: | eScholarship, University of California 2020-10-01 |
| تفاصيل مُضافة: | Karunamuni, Roshan A Huynh-Le, Minh-Phuong Fan, Chun C Eeles, Rosalind A Easton, Douglas F Kote-Jarai, ZSofia Amin Al Olama, Ali Benlloch Garcia, Sara Muir, Kenneth Gronberg, Henrik Wiklund, Fredrik Aly, Markus Schleutker, Johanna Sipeky, Csilla Tammela, Teuvo LJ Nordestgaard, Børge G Key, Tim J Travis, Ruth C Neal, David E Donovan, Jenny L Hamdy, Freddie C Pharoah, Paul Pashayan, Nora Khaw, Kay-Tee Thibodeau, Stephen N McDonnell, Shannon K Schaid, Daniel J Maier, Christiane Vogel, Walther Luedeke, Manuel Herkommer, Kathleen Kibel, Adam S Cybulski, Cezary Wokolorczyk, Dominika Kluzniak, Wojciech Cannon-Albright, Lisa Brenner, Hermann Schöttker, Ben Holleczek, Bernd Park, Jong Y Sellers, Thomas A Lin, Hui-Yi Slavov, Chavdar Kaneva, Radka Mitev, Vanio Batra, Jyotsna Clements, Judith A Spurdle, Amanda Australian Prostate Cancer BioResource (APCB) Teixeira, Manuel R Paulo, Paula Maia, Sofia Pandha, Hardev Michael, Agnieszka Mills, Ian G Andreassen, Ole A Dale, Anders M Seibert, Tyler M PRACTICAL Consortium |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 SNPs per subject, and was split into training and testing sets. Established-SNP models considered 65 SNPs that had been previously associated with prostate cancer. Discovery-SNP models used stepwise selection to identify new SNPs. The performance of each PHS model was calculated for random sizes of the training set. The performance of a representative Established-SNP model was estimated for random sizes of the testing set. Mean HR98/50 (hazard ratio of top 2% to average in test set) of the Established-SNP model increased from 1.73 [95% CI: 1.69-1.77] to 2.41 [2.40-2.43] when the number of training samples was increased from 1 thousand to 30 thousand. Corresponding HR98/50 of the Discovery-SNP model increased from 1.05 [0.93-1.18] to 2.19 [2.16-2.23]. HR98/50 of a representative Established-SNP model using testing set sample sizes of 0.6 thousand and 6 thousand observations were 1.78 [1.70-1.85] and 1.73 [1.71-1.76], respectively. We estimate that a study population of 20 thousand men is required to develop Discovery-SNP PHS models while 10 thousand men should be sufficient for Established-SNP models. |
| مصطلحات الفهرس: | Australian Prostate Cancer BioResource, PRACTICAL Consortium, Humans, Prostatic Neoplasms, Proportional Hazards Models, Sample Size, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Models, Genetic, Male, Clinical Trials as Topic, Genome-Wide Association Study, Aging, Cancer, Urologic Diseases, Prostate Cancer, Genetics, Clinical Sciences, Genetics & Heredity, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf European journal of human genetics : EJHG vol 28, iss 10, 1467-1475 1018-4813 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt6rq0c7z3 qt6rq0c7z3 https://escholarship.org/uc/item/6rq0c7z3Test https://escholarship.orgTest/ 1367400788 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1367400788 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |