مورد إلكتروني
First age- and gender-matched case-control study in Australia examining the possible association between toxoplasma gondii Infection and type 2 diabetes mellitus: The Busselton Health Study
| العنوان: | First age- and gender-matched case-control study in Australia examining the possible association between toxoplasma gondii Infection and type 2 diabetes mellitus: The Busselton Health Study |
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| المصدر: | Research outputs 2014 to 2021 |
| بيانات النشر: | Edith Cowan University, Edith Cowan University, Research Online, Perth, Western Australia, Perth, Western Australia 2020-01-01T08:00:00Z |
| تفاصيل مُضافة: | Molan, Aus Nosaka, Kazunori Hunter, Michael Zhang, Jinxia Meng, Xiaoni Song, Manshu Wang, Wei |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | An emerging field of research is starting to examine the association of infectious pathogens with type 2 diabetes mellitus (T2DM). An understudied parasite of interest is Toxoplasma gondii. Globally, very few studies have been conducted to investigate this association. Additionally, very little data exists on the prevalence of T. gondii in the general Australian population. Our group sought to determine the prevalence, association, and risk factors between T. gondii infection and T2DM from a representative Australian human population. Through a cross-sectional, age-A nd gender-matched case-control study, 150 subjects with T2DM together with 150 control subjects from the Busselton Health Study cohort were investigated. Sera samples were tested for the presence of anti-T. gondii IgG and IgM antibodies using enzyme-linked immunosorbent assays. Survey-derived data were also analyzed to evaluate associated risk factors. The IgG seroprevalence was found to be 62% and 66% for the T2DM and control groups, respectively (OR:0.84; p=0.471). IgM antibodies were detected in 5% of the T2DM patients and in 10% of the controls (OR=0.51; p=0.135). There were no significant differences between male and female IgG seroprevalence rates for both groups (OR:0.88, 0.80; p=0.723). The IgG seropositivity rate increased significantly in T2DM patients aged 45-84 years in comparison to those aged 18-44 years (p< 0.05), but this was not observed in the control subjects. No risk factors were associated with T. gondii seropositivity in both groups. The first Australian study of its kind found T. gondii infection in Western Australia to be highly prevalent. The results also showed that there is no serological evidence of an association between T. gondii infection and T2DM in the studied subjects. Australian health authorities should focus on raising awareness of toxoplasma infection and target T. gondii transmission control. Further studies are needed to clarify the role of T. gondii in T2DM. © 20 |
| مصطلحات الفهرس: | [RSTDPub], immunoglobulin G antibody, immunoglobulin M antibody, parasite antibody, adult, age, aged, antibody detection, Article, Australia, Australian, blood sampling, case control study, cohort analysis, controlled study, cross-sectional study, disease association, enzyme linked immunosorbent assay, female, health survey, human, infection risk, major clinical study, male, non insulin dependent diabetes mellitus, population based case control study, prevalence, risk assessment, risk factor, seroprevalence, sex difference, toxoplasmosis, Medicine and Health Sciences, text |
| URL: | |
| الإتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by/4.0Test |
| ملاحظة: | application/pdf Research outputs 2014 to 2021 |
| أرقام أخرى: | ER0 oai:ro.ecu.edu.au:ecuworkspost2013-9086 https://ro.ecu.edu.au/ecuworkspost2013/8080Test info:doi/10.1155/2020/3142918 https://ro.ecu.edu.au/context/ecuworkspost2013/article/9086/viewcontent/First_age_a_nd_gender_matched_case_control_study_in_Australia_examining_the_possible_association_between_toxoplasma_gondii_Infection_and_type_2_diabetes_mellitus_The_Busselton_Health_Study.pdfTest 1366585981 |
| المصدر المساهم: | EDITH COWAN UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1366585981 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |