مورد إلكتروني
A pervasive role of histone acetyltransferases and deacetylases in an NF-kappaB-signaling code.
| العنوان: | A pervasive role of histone acetyltransferases and deacetylases in an NF-kappaB-signaling code. |
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| المصدر: | Trends in biochemical sciences, 33 (7 |
| بيانات النشر: | 2008 |
| تفاصيل مُضافة: | Calao, Miriam Burny, Arsène Quivy, Vincent Dekoninck, Ann Van Lint, Carine |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Most nuclear factor-kappaB (NF-kappaB) inducers converge to activate the IkappaB kinase (IKK) complex, leading to NF-kappaB nuclear accumulation. However, depending on the inducer and the cell line, the subset of NF-kappaB-induced genes is different, underlining a complex regulation network. Recent findings have begun to delineate that histone and non-histone protein acetylation is involved, directly and indirectly, in controlling the duration, strength and specificity of the NF-kappaB-activating signaling pathway at multiple levels. Acetylation and deacetylation events, in combination with other post-translational protein modifications, generate an 'NF-kappaB-signaling code' and regulate NF-kappaB-dependent gene transcription in an inducer- and promoter-dependent manner. Indeed, the intricate involvement of histone acetyltransferases and histone deacetylases modulates both the NF-kappaB-signaling pathway and the transcriptional transactivation of NF-kappaB-dependent genes. Journal Article Research Support, Non-U.S. Gov't Review info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Sciences bio-médicales et agricoles, Animals, Histone Acetyltransferases -- metabolism, Histone Deacetylases -- metabolism, Humans, Models, Biological, NF-kappa B -- metabolism, Signal Transduction -- physiology, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content 1 full-text file(s): info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | 1 full-text file(s): application/pdf English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/51786 uri/info:doi/10.1016/j.tibs.2008.04.015 uri/info:pii/S0968-0004(08)00124-2 uri/info:pmid/18585916 uri/info:scp/46149125241 1363714063 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1363714063 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |