مورد إلكتروني
Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress
| العنوان: | Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress |
|---|---|
| المصدر: | Neuropsychobiology |
| بيانات النشر: | 2005 |
| تفاصيل مُضافة: | Filipović, Dragana Gavrilović, Ljubica Dronjak, Slađana Radoičić, Marija B. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The pattern and intensity of glucocorticoid receptor (GR) and heat shock 70 protein (Hsp 70) changes in the hippocampus and brain cortex of adult Wistar rat males exposed to acute (immobilization, cold) and chronic (social isolation, crowding, daily swimming) stress or their combinations were followed by Western immunoblotting. Plasma ACTH and CORT were measured by chemiluminescent method and RIA. A significant decrease in cytosol GR and Hsp 70 was observed after acute stress, while chronic stresses led to negligible changes in both these proteins and caused a reduced responsiveness to a novel acute stress. This was valid irrespective of the type of chronic or acute stress combinations for both hippocampal and cortical GR and Hsp 70. The results support the hypothesis that chronic stress-induced deregulation of the LHPA axis may be caused, at least in part, by partial disruption of intracelullar negative feedback control in the higher centers of the brain. Copyright (C) 2005 S. Karger AG, Basel. |
| مصطلحات الفهرس: | stress, glucocorticoid receptor, heat shock protein 70, hippocampus, brain cortex, article |
| الإتاحة: | Open access content. Open access content restrictedAccess |
| ملاحظة: | Neuropsychobiology |
| أرقام أخرى: | RSPST oai:vinar.vin.bg.ac.rs:123456789/2871 0302-282X 1423-0224 https://vinar.vin.bg.ac.rs/handle/123456789/2871Test 000227789600008 10.1159/000084168 15741752 2-s2.0-17144396312 1363255317 |
| المصدر المساهم: | UIVERSITY OF BELGRADE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1363255317 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |