مورد إلكتروني
CIDE-A, a novel link between brown adipose tissue and obesity
| العنوان: | CIDE-A, a novel link between brown adipose tissue and obesity |
|---|---|
| بيانات النشر: | 2004 |
| تفاصيل مُضافة: | Lin, SC Li, P. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Brown adipose tissue (BAT) is the major site of adaptive thermogenesis in rodents. The thermogenic activity of BAT is mediated by uncoupling proteins (Ucp1). Impaired BAT activity is believed to have an important role in the development of obesity. However, direct evidence linking BAT to obesity is scarce. Cidea, which was initially identified as a result of its sequence similarity to the apoptotic DNA fragmentation factor, is highly expressed in BAT. Mice that are deficient for Cidea showed an increase in energy expenditure and are resistant to high-fat diet-induced obesity and diabetes. Although the precise mechanism by which Cidea regulates energy homeostasis is not yet clear, Cidea appears to interact with Ucp1 in mammalian cells and inhibits its uncoupling activity when co-expressed in yeast. Therefore, Cidea offers a new option to explore the linkage between BAT and obesity. |
| مصطلحات الفهرس: | Adipose Tissue, Brown: metabolism, Animals, Apoptosis Regulatory Proteins, Carrier Proteins: metabolism, Disease Models, Animal, Energy Metabolism, Humans, Ion Channels, Lipid Metabolism, Membrane Proteins: metabolism, Mice, Mitochondrial Proteins, Obesity: metabolism, Proteins: genetics, Proteins: metabolism, Thermogenesis: physiology, Article |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | HNK oai:repository.hkust.edu.hk:1783.1-29532 Trends in molecular medicine, v. 10, (9), 2004, SEP, p. 434-439 1471-4914 https://doi.org/10.1016/j.molmed.2004.07.005Test 1331201317 |
| المصدر المساهم: | HONG KONG UNIV OF SCI & TECH, THE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1331201317 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |