مورد إلكتروني
Consanguinity and the developmental origins of health and disease
| العنوان: | Consanguinity and the developmental origins of health and disease |
|---|---|
| المصدر: | Research outputs 2014 to 2021 |
| بيانات النشر: | Edith Cowan University, Edith Cowan University, Research Online, Perth, Western Australia, Perth, Western Australia 2015-01-01T08:00:00Z |
| تفاصيل مُضافة: | Chisholm, James S. Bittles, Alan H. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Consanguineous marriage is strongly favored in many regions of the world, despite the prevalent Western belief that the progeny of close kin unions experience developmental disorders and premature mortality. Objective: We outline an alternative perspective on the association between consanguinity and disease, in terms of life history theory and the developmental origins of health and disease. Methods: Meta-analyses of 64 studies across 14 countries and four continents were performed, comprising some five million births to first-cousin, second-cousin, and nonconsanguineous couples. Results: First-cousin marriage was associated with a mean increase of 3.7% in all-causes mortality, which is significantly lower than the large majority of previous reports. First cousins also married younger and showed greater fertility (P<.0001), possibly reflecting arranged marriage and the maintenance of family property. Conclusions: These findings are consistent with predictions from life history theory. We propose that close kin unions may maximize current reproduction while minimizing reductions in offspring reproductive value under conditions of chronic intergenerational poverty and inequality. |
| مصطلحات الفهرس: | consanguinity, inbreeding depression, life history theory, developmental origins of health and disease, Medicine and Health Sciences, text |
| URL: | |
| الإتاحة: | Open access content. Open access content free_to_read |
| ملاحظة: | Research outputs 2014 to 2021 |
| أرقام أخرى: | ER0 oai:ro.ecu.edu.au:ecuworkspost2013-7854 https://ro.ecu.edu.au/ecuworkspost2013/6849Test https://doi.org/10.4303/jem/235909Test 1314881237 |
| المصدر المساهم: | EDITH COWAN UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1314881237 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |