مورد إلكتروني
Hepatic Lactate Dehydrogenase A : An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria
| العنوان: | Hepatic Lactate Dehydrogenase A : An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria |
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| بيانات النشر: | 2021 |
| تفاصيل مُضافة: | Ariceta Iraola, Gema Barrios, Kelly Brown, Bob D. Hoppe, Bernd Rosskamp, Ralf Langman, Craig B. Universitat Autònoma de Barcelona |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Primary hyperoxaluria (PH) is a family of 3 rare genetic disorders of hepatic glyoxylate metabolism that lead to overproduction and increased renal excretion of oxalate resulting in progressive renal damage. LDHA inhibition of glyoxylate-to-oxalate conversion by RNA interference (RNAi) has emerged as a potential therapeutic option for all types of PH. LDHA is mainly expressed in the liver and muscles. Nonclinical data in mice and nonhuman primates show that LDHA inhibition by RNAi reduces urinary oxalate excretion and that its effects are liver-specific without an impact on off-target tissues, such as the muscles. To confirm the lack of unintended effects in humans, we analyzed data from the phase I randomized controlled trial of single-dose nedosiran, an RNAi therapy targeting hepatic LDHA. We conducted a review of the literature on LDHA deficiency in humans, which we used as a baseline to assess the effect of hepatic LDHA inhibition. Based on a literature review of human LDHA deficiency, we defined the phenotype as mainly muscle-related with no liver manifestations. Healthy volunteers treated with nedosiran experienced no drug-related musculoskeletal adverse events. There were no significant alterations in plasma lactate, pyruvate, or creatine kinase levels in the nedosiran group compared with the placebo group, signaling the uninterrupted interconversion of lactate and pyruvate and normal muscle function. Phase I clinical data on nedosiran and published nonclinical data together provide substantial evidence that LDHA inhibition is a safe therapeutic mechanism for the treatment of all known types of PH. |
| مصطلحات الفهرس: | Lactate dehydrogenase A, Nedosiran, Primary hyperoxaluria, RNA interference, Small interfering RNA, Article |
| URL: | Kidney International Reports ; Vol. 6 (february 2021), p. 1088-1098 |
| الإتاحة: | Open access content. Open access content open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0Test |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | HGE oai:ddd.uab.cat:239858 https://ddd.uab.cat/record/239858Test urn:10.1016/j.ekir.2021.01.029 urn:oai:ddd.uab.cat:239858 urn:pmcid:PMC8071644 urn:pmc-uid:8071644 urn:pmid:33912759 urn:articleid:24680249v6p1088 urn::oai:pubmedcentral.nih.gov:8071644 1312226853 |
| المصدر المساهم: | UNIV AUTONOMA DE BARCELONA From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1312226853 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |