مورد إلكتروني
Renal (and herpetic) re-transplantation.
| العنوان: | Renal (and herpetic) re-transplantation. |
|---|---|
| بيانات النشر: | Blackwell Publishing 2014-08-22 |
| تفاصيل مُضافة: | Robertson A. Hughes P.D. Setyapranata S. Wiggins K.J. Holt S.G. Mulley W.R. Kerr P.G. Landgren A.J. Young A. Opdam H. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Aim: Case report of renal re-transplantation, reported only once previously. Report: A middle aged recipient received a kidney transplant from a deceased multi-organ donor. After initially doing well, the patient suffered cardiac arrest several days post-operatively and sustained hypoxic brain injury and was declared brain dead. Following the family's consent, the allograft kidney was retrieved and re-transplanted into a man with end-stage renal failure secondary to reflux nephropathy. The lungs were used in a separate recipient but the liver was not transplanted due to suspicion of fatty changes based on macroscopic appearance. Histological analysis of the liver more than 24 hours after transplantation of the other organs revealed coagulative parenchymal necrosis with nuclear inclusions and moderate parenchymal cholestasis, suggestive of herpes viral hepatitis. Examination of the renal implantation biopsy showed histiocytes with enlarged nuclei containing viral inclusions in the capsular fibrous tissue, with positive immunostaining for herpes simplex virus (HSV). Valaciclovir was started immediately after obtaining histological evidence of donor HSV infection and this was subsequently converted to intravenous ganciclovir. Our recipient had pre-formed IgG antibodies to HSV-1 and HSV-2, and was IgM negative pretransplant. HSV viraemia was detected day 5 post-transplant with a viral load of 7688 copies/mL by polymerase chain reaction (PCR) assay. He completed a 30-day course of intravenous ganciclovir before switching to valganciclovir as standard cytomegalovirus prophylaxis. The HSV PCR became undetectable on day 7 of IV ganciclovir and has remained undetectable. The patient remains well with an estimated glomerular filtration rate of 61 mL/min/1.73 m2 and further investigation of the apparent viral transmission is underway. Conclusion(s): We report good short term results of renal re-transplantation and HSV transmission by transplantation. |
| مصطلحات الفهرس: | virus hepatitis, allograft, middle aged, case report, brain, examination, implantation, kidney, immunohistochemistry, organ donor, infection, polymerase chain reaction, virus load, viremia, assay, Cytomegalovirus, prophylaxis, glomerulus filtration rate, virus transmission, biopsy, ganciclovir, valaciclovir, immunoglobulin G antibody, immunoglobulin M, valganciclovir, tissues, New Zealand, society, nephrology, transplantation, human, Herpes simplex virus, recipient, patient, liver, cell nucleus inclusion body, brain injury, lung, heart arrest, kidney graft, histiocyte, end stage renal disease, male, reflux nephropathy, donor, necrosis, cholestasis, herpes simplex, Conference Abstract |
| URL: | Click here for full text options LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2014 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/42332 Nephrology. Conference: 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology. Melbourne, VIC Australia. Conference Publication: (var.pagings). 19 (SUPPL. 4) (pp 89), 2014. Date of Publication: August 2014. 1320-5358 https://repository.monashhealth.org/monashhealthjspui/handle/1/42332Test 71588055 (Setyapranata, Wiggins, Holt, Landgren, Robertson, Hughes) Royal Melbourne Hospital, Melbourne, VIC, Australia (Holt) University of Melbourne, Melbourne, VIC, Australia (Mulley, Kerr) Monash Medical Centre, Melbourne, VIC, Australia (Young, Opdam) Donate Life Victoria, Melbourne, VIC, Australia (Setyapranata, Wiggins, Holt, Landgren, Robertson, Hughes) Royal Melbourne Hospital, Melbourne, VIC, Australia (Holt) University of Melbourne, Melbourne, VIC, Australia (Young, Opdam) Donate Life Victoria, Melbourne, VIC, Australia (Mulley, Kerr) Monash Medical Centre, Melbourne, VIC, Australia 1308882919 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1308882919 |
| قاعدة البيانات: | OAIster |
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