مورد إلكتروني
Macrophage accumulation in human progressive diabetic nephropathy.
| العنوان: | Macrophage accumulation in human progressive diabetic nephropathy. |
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| بيانات النشر: | Blackwell Publishing (550 Swanston Street, Carlton South VIC 3053, Australia) Australia 2012-10-17 |
| تفاصيل مُضافة: | Chadban S.J. Nguyen D. Ping F. Mu W. Hill P. Atkins R.C. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Diabetic nephropathy is a major global health problem. Progression to renal failure is common; however, the mechanisms are unknown. Experimental models suggest a role for macrophages. Therefore, macrophage accumulation and its relationship to the subsequent clinical course were studied. Method(s): A retrospective study of baseline histology and the subsequent clinical course over at least 5 years involving 20 consecutive patients with a histological and clinical diagnosis of diabetic nephropathy was performed. The relationship between macrophage accumulation in renal biopsy tissue (KP-1/anti-CD68+ cells), baseline measures of known predictors of progression (proteinuria, tubulointerstitial damage, myofibroblast accumulation) and progression over 5 years (plot of reciprocal of serum creatinine) was quantified. Result(s): Accumulation of macrophages was apparent in the glomeruli (2.8 + 0.7/gcs vs 1.0 + 0.2 for normals, P = not significant) and interstitium (296.9 + 63.3/mm2vs 19.0 + 1.3/mm2 for normals, P = 0.002) of patients with diabetic nephropathy. Glomerular macrophage number correlated with baseline serum creatinine (r = 0.548, P = 0.012) but not with progression of renal failure as glomerular macrophages were prevalent in early, but not advanced diabetic nephropathy. Interstitial macrophage accumulation correlated strongly with serum creatinine (r = 0.649, P = 0.002), proteinuria (r = 0.779, P < 0.0001), interstitial fibrosis (r = 0.774, P < 0.0001) and inversely with the slope of 1/serum creatinine (r = -0.531, P = 0.023). Conclusion(s): Macrophages accumulate within glomeruli and the interstitium in diabetic nephropathy and the intensity of the interstitial infiltrate is proportional to the rate of subsequent decline in renal function. These human data support animal studies that suggest a pathogenic role for the macrophage in diabetic nephropathy. © 2006 Asian Pacific Society of Nephrology. |
| مصطلحات الفهرس: | kidney biopsy, kidney failure, kidney tubule damage, macrophage, male, myofibroblast, prevalence, priority journal, proteinuria, retrospective study, human, human tissue, interstitium, article, clinical article, creatinine blood level, diabetic nephropathy/di [Diagnosis], disease course, female, fibrosing alveolitis, glomerulus, histology, statistical significance, creatinine/ec [Endogenous Compound], adult, aged, Article |
| URL: | Click here for full text options LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2012 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/32066 Nephrology. 11 (3) (pp 226-231), 2006. Date of Publication: June 2006. 1320-5358 https://repository.monashhealth.org/monashhealthjspui/handle/1/32066Test 16756636 [http://www.ncbi.nlm.nih.gov/pubmed/?term=16756636Test] 43829442 (Nguyen, Ping, Mu, Atkins, Chadban) Department of Nephrology, Monash Medical Centre, Clayton, Vic., Australia (Hill) Department of Anatomical Pathology, St. Vincent's Hospital, Fitzroy, Vic., Australia (Nguyen) Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam (Ping) Department of Nephrology, First University Hospital of WCUMS, Chengdu, Sichuan, China (Chadban) Transplantation, Royal Prince Alfred Hospital, Camperdown, NSW, Australia (Chadban) Transplantation, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia Chadban S.J.; steve.chadban@cs.nsw.gov.au 1305131267 |
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| رقم الانضمام: | edsoai.on1305131267 |
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