مورد إلكتروني
Continuous veno-venous hemofiltration with dialysis removes cytokines from the circulation of septic patients.
| العنوان: | Continuous veno-venous hemofiltration with dialysis removes cytokines from the circulation of septic patients. |
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| بيانات النشر: | Lippincott Williams and Wilkins (351 West Camden Street, Baltimore MD 21201-2436, United States) United States 2012-10-25 |
| تفاصيل مُضافة: | Tipping P. Boyce N. Bellomo R. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Objectives: To determine whether continuous veno-venous hemofiltration with dialysis leads to extraction of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) from the circulation of critically ill patients with sepsis and acute renal failure and to quantitate the clearance and removal rates of these cytokines and their effect on serum cytokine concentrations. Design(s): Prospective, controlled study of TNF-alpha and IL-1beta extraction by continuous veno-venous hemofiltration with dialysis in patients with septic acute renal failure. Setting(s): Intensive care unit of a tertiary institution. Patient(s): Eighteen critically ill patients with sepsis and acute renal failure. Control group of six patients experiencing an acute illness while undergoing chronic hemodialysis. Intervention(s): Collection of blood samples before continuous veno-venous hemofiltration with hemodialysis. Simultaneous collection of prefilter blood and ultradiafiltrate after 4 and 24 hrs of treatment. Measurements and Main Results: TNF-alpha and IL-1beta concentrations were measured in blood and ultradiafiltrate. Their clearances and daily extraction were calculated and compared with a control group. TNF-alpha was detected in 66.6% of serum samples of patients with septic acute renal failure; IL-1beta was detected in 55% of patients' sera samples. Both TNF-alpha and IL-1beta were cleared by the hemofilter during continuous veno-venous hemofiltration with dialysis. The mean clearance for TNF-alpha was 30.7 L/day (95% confidence interval 22.4 to 39) with a daily mean excretion of 14.1 mug (95% confidence interval 1.7 to 26.5). Mean IL-1beta clearance was 36.1 L/day (95% confidence interval 25.4 to 46.8) equivalent to a mean daily IL-1beta excretion of 1 mug (95% confidence interval 0.9 to 1.1). No measurable concentrations of TNF-alpha or IL-1beta were found in the serum or ultrafiltrate specimens of control patients. Conclusion(s): These findings demonstrate that continuous |
| مصطلحات الفهرس: | interleukin 1beta/ec [Endogenous Compound], tumor necrosis factor alpha/ec [Endogenous Compound], kidney failure/co [Complication], adult, article, controlled study, critical illness, fever/et [Etiology], hemodialysis, hemofiltration, human, infection/di [Diagnosis], kidney failure/th [Therapy], multiple organ failure/co [Complication], plasma clearance, priority journal, sepsis/co [Complication], sepsis/th [Therapy], Article |
| URL: | Click here for full text options LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2012 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/34427 Critical Care Medicine. 21 (4) (pp 522-526), 1993. Date of Publication: 1993. 0090-3493 https://repository.monashhealth.org/monashhealthjspui/handle/1/34427Test 8472571 [http://www.ncbi.nlm.nih.gov/pubmed/?term=8472571Test] 23121799 (Bellomo, Tipping, Boyce) Department of Medicine, Monash Medical Centre, Vic., Australia 1305130871 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305130871 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |