مورد إلكتروني
Ganaxolone: A novel treatment for neonatal seizures that is neuroprotective.
| العنوان: | Ganaxolone: A novel treatment for neonatal seizures that is neuroprotective. |
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| بيانات النشر: | Blackwell Publishing Netherlands 2018-04-06 |
| تفاصيل مُضافة: | Sutherland A. McDonald C. Pham Y. Mihelakis J. Nitsos I. Malhotra A. Allison B. Castillo-Melendez M. Walker D. Jenkin G. Miller S. Fahey M. Yawno T. Bennet L. Holt C. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Seizures in neonates are relatively common, and are strong predictors of long-term cognitive and developmental impairment. Current anti-seizure therapies (phenobarbitone) have the potential to be neurotoxic. We propose that ganaxolone, a GABAA agonist, will reduce seizures, and reduce markers of brain injury following hypoxia ischemia. We investigated the effects of ganaxolone or phenobarbitone, given at 6h following hypoxia ischemia. Method(s): Hypoxic ischemic encephalopathy (HIE) was induced via umbilical cord occlusion in term lambs. HIE lambs were treated with either ganaxolone or phenobarbitone from 6h following HI. Seizures were assessed using continuous amplitudeintegrated electroencephalogram (aEEG) recording. At 48h, lambs were euthanized for brain collection and analysis of neuropathology. Result(s): At birth, HIE lambs had a pH <7.0, base excess >12mmol/L, and blood pressure was reduced to 16.4 +/- 1.2 mmHg, indicating severe birth asphyxia. All HIE lambs demonstrated electrographic seizures (aEEG) and the mean number of seizures per hour (6-12hrs) was 4.8 +/- 2.2. Ganaxolone treatment reduced the number of seizures to 1.0 +/- 0.9 per hour, which was a greater reduction attributable to phenobarbitone (3.2 +/- 1.6 per hour). Brain histology revealed improved neuronal survival and reduced cell death in the cortex and basal ganglia after ganaxolone treatment, compared to phenobarbitone. Conclusion(s): Ganaxolone treatment in lambs with HIE decreased seizure activity and cell death, and improved neuronal survival. Ganaxolone may be a better therapy than phenobarbitone. |
| مصطلحات الفهرس: | drug therapy, alkalosis, animal experiment, animal model, animal tissue, basal ganglion, blood pressure, brain cortex, brain histology, cell death, controlled study, electroencephalogram, hypoxic ischemic encephalopathy, infantile spasm, lamb, neuropathology, nonhuman, occlusion, perinatal asphyxia, umbilical cord, ganaxolone, phenobarbital, conference abstract, Conference Abstract |
| URL: | Click here for full text options LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2018 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/38157 Journal of Paediatrics and Child Health. Conference: 22nd Annual Congress of the Perinatal Society of Australia and New Zealand, PSANZ 2018. Auckland New Zealand. 54 (Supplement 1) (pp 127), 2018. Date of Publication: March 2018. 1440-1754 https://repository.monashhealth.org/monashhealthjspui/handle/1/38157Test 621532572 (Yawno, Holt, Sutherland, McDonald, Pham, Mihelakis, Nitsos, Allison, Castillo-Melendez, Jenkin, Miller) Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia (Bennet) University of Auckland, Auckland, New Zealand (Malhotra, Fahey) Monash Children's Hospital, Melbourne, Australia (Walker) RMIT University, Bundoora, Australia Yawno T.; tamara.yawno@hudson.org.au (Yawno, Holt, Sutherland, McDonald, Pham, Mihelakis, Nitsos, Allison, Castillo-Melendez, Jenkin, Miller) Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia (Bennet) University of Auckland, Auckland, New Zealand (Walker) RMIT University, Bundoora, Australia (Malhotra, Fahey) Monash Children's Hospital, Melbourne, Australia 1305128246 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305128246 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |