مورد إلكتروني
Prevention of vertical transmission of hepatitis B: An evaluation of adherence rates and risk factors for failure to provide immunoprophylaxis therapy in a single Australian centre.
| العنوان: | Prevention of vertical transmission of hepatitis B: An evaluation of adherence rates and risk factors for failure to provide immunoprophylaxis therapy in a single Australian centre. |
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| بيانات النشر: | Elsevier 2015-07-10 |
| تفاصيل مُضافة: | Ha P. Bull V. Lickliter E. Lewis J. Trivedi T. Le S. Dev A. Tan N. Sahhar L. Spring S. Birkett W. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background and Aims: Immune prophylaxis therapy (IPT) is well established in decreasing perinatal transmission of hepatitis B virus (HBV) and is a key strategy to reduce the prevalence of chronic hepatitis B (CHB) worldwide. Universal guidelines recommend administration of HBV immunoglobulin (HBIg) and HBV vaccine within 12 hours of birth. Immunisation adherence rates and risk factors for failure to provide timely IPT to babies born to CHB mothers remain poorly defined. We conducted a retrospective cohort study to determine compliance with IPT guidelines in routine obstetric practice at Monash Health, Australia. Method(s): 451 mothers with CHB delivered 451 live born infants at Monash Health between 2008 and 2013. There were 3 stillbirths and 3 sets of twin livebirths. Demographic and disease data, referral rates for specialist HBV care, neonatal and maternal morbidity outcomes and timing of HBIg and HBV vaccine administration were extracted from hospital records. Multivariate logistic regression analysis was utilized to identify the risk factors associated with failure to provide timely administration of IPT. Result(s): 47.23% of CHB mothers were diagnosed on routine antenatal screening. Mean maternal age was 30.37+/-5.25 years and mean gestational age was 38.99+/-2.50 weeks. 55.67% of women received antenatal specialist care for CHB and 4.29% commenced prophylactic antiviral therapy in the third trimester. 79.82% of newborns received HBIg within 12 hours and 8 babies received no HBIg prior to discharge (1 due to withdrawal of parental consent). 97.12% of newborns received HBV vaccine within 12 hours and 1 baby received no HBV vaccination prior to discharge. On multivariate analysis, antenatal care provided by an Obstetrician and or a Specialist for CHB was associated with timely administration of HBIg (OR 1.64, p = 0.038, CI:1.03-2.61). The requirement for an interpreter at birth, maternal age and parity, post-partum complications, gestational age and neonatal mor |
| مصطلحات الفهرس: | immunization, parental consent, antiviral therapy, multivariate analysis, newborn morbidity, follow up, cohort analysis, Australia, stillbirth, prophylaxis, multivariate logistic regression analysis, screening, medical record, third trimester pregnancy, maternal morbidity, prenatal care, obstetrician, twins, vaccine, immunoglobulin, vaccination, liver, hepatitis B, Australian, risk factor, immunoprophylaxis, therapy, European, vertical transmission, prevention, human, Hepatitis B virus, female, mother, medical specialist, baby, maternal age, newborn, health, infant, gestational age, chronic hepatitis B, prevalence, parity, Conference Abstract |
| URL: | Click here for full text options LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2015 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/41423 Journal of Hepatology. Conference: 50th Annual Meeting of the European Association for the Study of the Liver, International Liver Congress 2015. Vienna Austria. Conference Publication: (var.pagings). 62 (SUPPL. 2) (pp S544), 2015. Date of Publication: April 2015. 0168-8278 https://repository.monashhealth.org/monashhealthjspui/handle/1/41423Test Monash Health 71937323 (Sahhar, Spring, Ha, Tan, Bull, Birkett, Lickliter, Lewis, Trivedi) Monash University, Clayton, Australia (Le, Dev) Dept of Gastroeneterology, Monash Health, Clayton, Australia Sahhar L.; lukas.sahhar@gmail.com (Sahhar, Spring, Ha, Tan, Bull, Birkett, Lickliter, Lewis, Trivedi) Monash University, Clayton, Australia (Le, Dev) Dept of Gastroeneterology, Monash Health, Clayton, Australia 1305127716 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305127716 |
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