مورد إلكتروني
Renal allograft re-use and herpetic re-infection.
| العنوان: | Renal allograft re-use and herpetic re-infection. |
|---|---|
| بيانات النشر: | Blackwell Publishing (E-mail: info@asia.blackpublishing.com.au) Australia 2015-04-08 |
| تفاصيل مُضافة: | Opdam H. Robertson A. Asadi K. Hughes P.D. Setyapranata S. Holt S.G. Wiggins K.J. Mulley W.R. Kerr P.G. Landgren A.J. Eisen D.P. Young A. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | A middle-aged man received a kidney transplant from a deceased multi-organ donor. The recipient suffered cardiac arrest several days post-operatively and sustained hypoxic brain injury and was declared brain dead. Following the family's consent, the allograft kidney was retrieved and re-transplanted into a man with end-stage renal failure secondary to reflux nephropathy. The liver was not transplanted due to suspicion of fatty changes based on macroscopic appearance. After transplantation of other organs, liver histology revealed coagulative parenchymal necrosis with nuclear inclusions and moderate parenchymal cholestasis, suggestive of herpes viral hepatitis. Renal implantation biopsy showed histiocytes with enlarged nuclei containing viral inclusions in the capsular fibrous tissue, with positive immunostaining for herpes simplex virus (HSV). Anti-viral therapy was commenced immediately after obtaining histological evidence of donor HSV infection. Our recipient had pre-formed immunoglobulin G antibodies to HSV-1 and HSV-2, and was immunoglobulin M negative pre-transplant. HSV viraemia was detected day 5 post-transplant with a viral load of 7688 copies/mL by polymerase chain reaction assay. The recipient completed a 30 day course of intravenous ganciclovir before switching to oral valganciclovir as standard cytomegalovirus prophylaxis. The HSV polymerase chain reaction became undetectable on day 7 of intravenous ganciclovir and has remained undetectable. The patient remains well 9 months post-transplant with an estimated glomerular filtration rate of 61 mL/min per 1.73 m2. Although renal allograft re-use has been shown to be technically possible with a good outcome in this recipient, this does raise issues including assessment of allografts that have undergone repeated severe ischaemic insults and the potential of transmission of infections.Copyright © 2015 Asian Pacific Society of Nephrology. |
| مصطلحات الفهرس: | end stage renal disease/su [Surgery], glomerulus filtration rate, graft infection/co [Complication], graft recipient, heart arrest, heart infarction, heart massage, herpes simplex/co [Complication], herpes simplex/dt [Drug Therapy], Herpes simplex virus 1, Herpes simplex virus 2, histiocyte, hospital admission, human, hyperlipidemia, hypertension, immunohistochemistry, immunosuppressive treatment, infection prevention, informed consent, insulin dependent diabetes mellitus, intubation, ischemic heart disease, kidney allograft, kidney biopsy, kidney donor, kidney pancreas transplantation, liver histology, liver necrosis, lung transplantation, maintenance therapy, male, middle aged, nonhuman, oliguria/th [Therapy], organ donor, partial thromboplastin time, patient history of therapy, polymerase chain reaction, priority journal, reflux nephropathy/su [Surgery], reinfection/co [Complication], resuscitation, retransplantation, review, serology, viremia, virus detection, virus load, virus transmission, alanine aminotransferase/ec [Endogenous Compound], aspartate aminotransferase/ec [Endogenous Compound], basiliximab, ganciclovir/dt [Drug Therapy], ganciclovir/iv [Intravenous Drug Administration], immunoglobulin G antibody/ec [Endogenous Compound], tacrolimus, unclassified drug, valganciclovir/dt [Drug Therapy], valganciclovir/po [Oral Drug Administration], virus antibody/ec [Endogenous Compound], herpes simplex virus antibody/ec [Endogenous Compound], drug substitution, inotropic agent, methylprednisolone, mycophenolic acid, prednisolone/po [Oral Drug Administration], acute kidney tubule necrosis, adult, aged, alanine aminotransferase blood level, antiviral therapy, aspartate aminotransferase blood level, bare metal stent, body rash, brain death, brain hypoxia, case report, cell nucleus inclusion body, cerebrospinal fluid, cholestasis, continuous hemofiltration, cytomegalovirus infection/dt [Drug Therapy], cytomegalovirus infection/pc [Prevention], delayed graft function/th [Therapy], diverticulosis, drug withdrawal, Review |
| URL: | Nephrology LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2015 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/40797 Nephrology. 20 (S1) (pp 17-21), 2015. Date of Publication: 01 Mar 2015. 1320-5358 https://repository.monashhealth.org/monashhealthjspui/handle/1/40797Test 25807853 [http://www.ncbi.nlm.nih.gov/pubmed/?term=25807853Test] 603441525 (Setyapranata, Holt, Wiggins, Robertson, Hughes) Department of Nephrology, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia (Mulley, Kerr) Department of Anatomical Pathology, Royal Melbourne Hospital, Melbourne, VIC, Australia (Landgren) Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, VIC, Australia (Eisen) Department of Nephrology, Monash Medical Centre, Melbourne, VIC, Australia (Young, Opdam) Donate Life Victoria, Melbourne, VIC, Australia (Asadi) Department of Anatomical Pathology, Austin Hospital, Melbourne, VIC, Australia Setyapranata S.; stella.setyapranata@gmail.com 1305121554 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305121554 |
| قاعدة البيانات: | OAIster |
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